Genomics and Neurobiology

Genomics

Analysis if the human genome plays an increasingly important role in society. In healthcare, genetic analysis is increasingly used in both diagnostics and as part of precision medicine, optimising individualised diagnostics and treatment. Studying the human genome is important both at the individual level where rare variants may increase the risk for disease, and in large population cohorts to understand the association between genotype and phenotype. Important progress is also being made in using genetics in forensics and studies of ancient DNA for new insights into human history.

Within the research programme there are research groups studying all these aspects of genetics, using and developing new methods and statistical analyses to the understanding of the human genome and how genetic variation is associated with specific traits.

Neurobiology

Functional neuronal networks, also known as neural circuits, constitute the fundamental units for information processing in the nervous systems. Research on these networks, particularly in rodents and fish, has unveiled fascinating insights into how neurons interact to regulate various behaviours and cognitive functions.

In mice, studies have elucidated the intricacies of sensory perception, motor function, spatial navigation, and social behaviours, shedding light on fundamental principles of neural circuit organization and function. Similarly, investigations in zebrafish have provided valuable knowledge about sensory-motor integration, decision-making processes, and the neural basis of complex behaviours like schooling and predator avoidance.

The comparative approach across these diverse species not only enhances our understanding of the evolutionary conservation of neural circuits but also offers valuable perspectives for translational research aimed at addressing neurological disorders and developing novel therapeutic interventions. Our research groups use mice and zebrafish to interrogate circuits responsible for pain and itch sensation, generation of motor behaviour, and memory formation.