Kost, biomarkörer och läkemedel för att predicera och förebygga frakturer bland kvinnor och män
Tidsperiod: 2020-01-01 till 2023-12-31
Projektledare: Karl Michaëlsson
Medarbetare: Håkan Melhus, Liisa Byberg, Susanna Larsson, Susanna C Larsson, Rikard Landberg, Bodil Svennblad, Jörg Schilcher
Budget: 4 800 000 SEK
The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended by use of a large cohort to evaluate real-world long-term risk to benefit of bone-specific drugs as well as calcium and vitamin D supplementation for the prevention of frailty fractures. The other three projects take advantage of a national cohort and biobank research infrastructure. We need better definition of true vitamin D deficiency and vitamin D stores in fat tissue has largely been neglected. The second project therefore focus by usage of the infrastructure to estimate the amount of vitamin D in fat by season and evaluate whether these fat depots of vitamin D can improve fracture prediction compared to plasma vitamin D alone. Much previous efforts on fracture prevention has been put on calcium intake but a healthy diet rich in fruit and vegetables seems not only to be of importance for health in general but also to maintain bone and muscle mass, and for prevention of frailty fractures. We will accordingly determine whether the needed intake of calcium for the prevention of fractures and low bone mineral density is modified by a healthy diet score. Last, by an exploratory design with discovery and replication cohorts, we will identify novel biomarkers of risk for frailty fractures, BMD and muscle mass using metabolomics, proteomics, genomics and lifestyle information.