En utvärdering av hur kunskap om genetisk arkitektur och genfunktion kan effektivisera genombaserad husdjurförädling - en studie av tillväxtens genetik i två stora experimentella hönspopulationer

Tidsperiod: 2019-01-01 till 2021-12-31

Projektledare: Örjan Carlborg

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 3 000 000 SEK

Genomic selection is a biotechnologically based approach to animal and plant breeding. It is efficient for closely related individuals, but less efficient for distantly related ones. It is therefore less useful in crossbreeding programs for chicken and pigs. Our purpose is to reveal how whole-genome sequence information and insights about the genetic architecture of agriculturally important traits can be used to improve genomic predictions in such applications.We aim to:Empirically explore the influence of high-order genetic interactions (epistasis) on genomic predictions of chicken growth. 16,000 Chinese indigenous x Commercial meat-type intercross chickens will be sequenced (CAU; Year 1) for mapping high-order genetic interactions influencing juvenile body weight (UU; Year 1-2). Interactions bias genomic predictions in yeast, it will be revealed if this needs to be accounted for in animals (UU; Year 2-3).Fine-map (Year 1-2; UU) and functionally dissect (Year 1-3; CAU) loci in the CAU population. Focus will be loci that replicate in an intercross from UU with ~4,000 whole-genome sequenced and phenotyped birds. This will reveal how the effects of functional variants are best captured and used in genomic predictions across populations.Integration of the computational (UU) and functional (CAU) genetics research programs will deliver fundamental knowledge for improving genomic selection in the two foremost sources of meat – chicken and pigs.