Höftprotes — Nya strategier för att förutsäga och förhindra tidiga komplikationer
Tidsperiod: 2019-01-01 till 2021-12-31
Projektledare: Nils Hailer
Medarbetare: Karl Michaëlsson, Josef Järhult, Olof Sköldenberg, Ola Rolfson
Budget: 2 400 000 SEK
Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. The incidence of both PJI and dislocation has increased substantially. Our aim is to predict and prevent these two major adverse events:1) Tools to identify high-risk individualsMethodology: Register-based development of prediction modelsGoal: Assessment of the risk of PJI or dislocation within a mobile App2) Implants that minimize the risk of PJIMethodology: Experimental in vitro-study on titanium implants, coated either with nano-silver or with absorbable hyaluronic-acid hydrogels carrying antibioticsOutcomes: Antibacterial effects are assessed by determining bacterial counts after inoculation of coated and uncoated implants. The osteoconductivity of modified implants is measured by culturing osteoblasts on these implants.3) Safety and efficacy of dual mobility cupsMethodology: Nationwide, register-nested randomized controlled trial on dual mobility cups that supposedly reduce the risk of dislocation. Patients scheduled for primary THA due to femoral neck fracture are randomized to either a dual mobility or a conventional cup.Outcomes: The primary outcome is occurrence of dislocation, secondary outcomes are re-operations, PJI, and mortality. 337 patients are required per study arm.The proposed strategies should reduce the prevalence of two disastrous THA complications.