Evolution och Kontroll av Genetisk Rekombination

Tidsperiod: 2016-01-01 till 2018-12-31

Projektledare: Jonas Berglund

Finansiär: Vetenskapsrådet

Bidragstyp: Bidrag för anställning eller stipendier

Budget: 3 150 000 SEK

Genetic recombination is central to evolution that serves as the unifying principle in the biology of higher organisms. This project will investigate how fine-scale recombination rate is controlled and how it evolves. I will contrast recombination in species that have lost a gene central to recombination control (PRDM9) with recombination in species where this gene remains active. This will allow me to identify genomic changes responsible for change in recombination rate and thereby infer mechanisms of control. It will also allow me to address how genome evolution is affected by recombination. Dr. Munch and I will collaborate on the proposed research to strike a balance between research independence and intensive research training. At the host institution I will be able develop new skills in genomic analysis that will feed back into my current research environment. My work will focus on the effects of PRDM9 and biased gene conversion, while Dr. Munch will focus on constructing the ancestral recombination maps. This will allow me to track the evolution of recombination rate along individual branches of the species tree and link it to the causative genomic changes. This basic genomic research is of great importance for the entire field of evolution to correctly quantify natural selection and infer demographic parameters. It provides the basis for mapping traits in population genetics, and enables accurate identification of biological mechanisms in molecular biology.