Hjärnavbildning av placeboinducerad smärtlindring från barndom till vuxenår hos migränpatienter och friska personer

Tidsperiod: 2015-01-01 till 2017-12-31

Projektledare: Vanda Faria

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 3 150 000 SEK

Whereas in clinical trials placebos are used as controls and high placebo effects adversely impact the evaluation of new treatments, in clinical practice high placebo responsivity provide welcoming therapeutic benefits, especially in the pediatric field where placebo responses are high and there is little known about the noxious impact of chronic drug use. Imaging studies have been instrumental in providing insights into the mechanisms behind placebo effects particularly in placebo analgesia. However, the majority of imaging research has been performed with adult healthy subjects. To translate the scientific knowledge into improved patient care, we need to understand how placebos exert their effects in clinical populations across developmental stages. By means of functional magnetic resonance imaging (fMRI), this project aims to examine for the first time prepubertal, postpubertal and adult neural mechanisms underlying placebo analgesia in patients with interictal (pain free) migraine and healthy controls. Migraine constitutes a good clinical model not only due to high placebo analgesic responsivity but also due to the interictal state, which provides a unique opportunity to examine placebo analgesia in brains affected by migraine without the confounding effects of ongoing pain. The PAIN group at Harvard has extensive knowledge on migraine. This study has tremendous methodological and clinical implications for the field of migraine and for the field of placebo in general.