Hjärnans reglering av födointag och belöning
Tidsperiod: 2014-01-01 till 2016-12-31
Budget: 3 900 000 SEK
We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We created a conditional Cre-Lox knock out mice lines of a novel gene that we have shown transports glutamate and is mainly found in outer membrane of GABA neurons, a unique mechanism for glutamate transport. Interestingly, this mouse line has enhanced reward system, eats more, and has functional memory deficits. We have shown that a gene coding for a methylation enzyme (FTO) is involved in energy driven hypothalamic food intake and that genetic variant are associated methylation in humans. We also showed associations of obesity with volumes of specific brain areas, that sleep deprivation affects hedonic signalling in humans and eating behaviour, and that insulin resistance is negatively correlated with verbal fluency and brain volumes. We evaluate the effect of cognitive treatments of anorexia and the effect of bariatric surgery on functional brain activity using fMRI. The studies are important for development of effective therapeutic approaches based on individualised diagnostic tests. The total impact of the published papers is steadily growing, being over 100 per year during the last three years, and publications with the PI have received more than 4500 citations 2010-2012. The group behind this application is strong, including several very productive post doctoral fellows, seven Ph.D. students, guest researchers and several term students.