Bortom Gleason gradering - Malignitetsgradering av prostate cancer med bildanalys teknik

Tidsperiod: 2013-01-01 till 2014-12-31

Projektledare: Ingrid Carlbom

Medarbetare: Christer Busch, Ewert Bengtsson, Marene Landström, Maréne Landström

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 1 545 000 SEK

Prostate cancer is the leading cause of death in men. The diagnosis and prognosis is based on Gleason grading which is the most widely used system for determining the severity of prostate cancer from tissue samples. However, Gleason grading is highly subjective with significant variation between experienced pathologists. Today about 70% of patients with localized prostate cancer receive aggressive treatment that does not prolong life but often results in debilitating side effects.The aim of this research is to replace subjective diagnosis of prostate cancer with automatic and objective severity grading based on morphological features that correlate to the disease outcome and that also incorporates several other markers for a more accurate prognostication. With the new tissue stains and a new method for highly accurate color decomposition that we have developed, we will automatically extract morphological features from images of prostate tissue samples that are known to be linked to cancer. Using biopsy and prostatectomy material with a consensus Gleason grade, we will develop new classifiers that reliably identify malignancy relative to disease end points combining morphological features and new biomarkers. Training the classifiers on the disease outcome rather than on the Gleason grade, will lead to better prognostication than currently possible.