FRAMTIDENS BIOLOGI VID AVANCERADE FOTONKÄLLOR

Tidsperiod: 2011-01-01 till 2015-12-31

Projektledare: Janos Hajdu

Finansiär: Vetenskapsrådet

Bidragstyp: Projektbidrag

Budget: 14 000 000 SEK

This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the development of software for processing, interpreting and validating diffraction data in structural biology (EMBL, Hamburg). The planned work is linked to four RÅC facilities: PETRA III, FLASH, XFEL (Hamburg) and MAX IV (Lund). Our laboratories will join forces over the next five years to (i) work out procedures for dealing with the torrent of diffraction data from coherent X-ray sources, (ii) develop new software to improve the interpretation of results from coherent diffractive imaging experiments, (iii) advance the integration of sample environment for bringing a broad variety of biological objects within the scope of detailed structural studies with the large scale facilities available to us in Hamburg. Uppsala and EMBL-Hamburg have highly complementary expertise in the relevant areas and are committed to put significant synergetic efforts into this project. The project is also necessary and timely. The results will benefit structural biologists at synchrotrons and X-ray lasers around the world. An additional aim of this proposal is to prepare us for an XFEL-based User Consortium jointly with the EMBL. The aim of the planned consortium is to establish an integrated biology infrastructure at XFEL in response to a recent call for User Consortia by XFEL.