Forskning vid Uppsala universitet

Forskningsprojekt från 2020-01-01 till 2023-12-31

Several nanosafety projects have been funded by the EU (e.g. EU Nanosafety Cluster and SmartNanoTox), however, the standardized process to assess and to predict the toxicity of metal oxide nanoparticles ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

We propose the development of a new class of accelerated recursive expansion methods for electronic structure calculations. Our aim is to substantially reduce the computational effort required by modern ...

Forskningsprojekt från 2015-11-01 till 2015-11-30

Conference name and location: Advancing the Frontiers of (Bio)Chemistry with Valence Bond Approaches. Uppsala University, Sweden.Time for the conference (year-month-day): 2016/06/22-24Justification of ...

Forskningsprojekt från 2017-02-01 till 2018-06-30

Syfte och mål: Projektet hade två mål; (i) att knyta långsiktiga forskningskontakter mellan min grupp vid UU och AstraZeneca och (ii) att utveckla den s.k. foto-SNAr reaktionen. Båda målen har uppfyllts ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

How can we study inherently dynamic and heterogeneous architectures of protein complexes? Most techniques struggle with heterogeneous systems, especially when lowly populated states are crucial for the ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

Forskningsprojekt från 2017-01-01 till 2017-03-13

G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Hip fractures annually affect almost 20,000 patients in Sweden. In about 2,000 patients with displaced femoral neck fractures insertion of a total hip arthroplasty (THA) is the best available treatment ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

I Sverige drabbas varje år 70000 individer av en fragilitetsfraktur. Med en livstidstidsrisk om 50 % för kvinnor och 25 % hos män har Sverige en av de högsta förekomsterna i världen av dessa frakturer. ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the intestinal fluid ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Background and aimFemoral neck fractures (FNFs) are a great challenge for today´s healthcare and they are associated with high mortality and morbidity in the elderly. The treatment of displaced FNF has ...

Forskningsprojekt från 2016-06-01 till 2017-11-30

Syfte och mål: Syftet med projektet var att genom individrörlighet skapa ett utbyte av kunskap och metoder inom läkemedelsutveckling mellan forskare vid Uppsala universitet och AstraZeneca Gothenburg. ...

Forskningsprojekt från 2015-07-01 till 2018-06-30

One important role of computer aided drug design is to guide modifications of ligands to improve binding to the protein target. Free energy perturbation (FEP) is one of the most rigorous methods to calculate ...

Forskningsprojekt från 2018-10-01 till 2018-11-30

Syfte och mål: Jag deltog i programmet Framtidens Ledare vid STS Forum i Kyoto. Ledande forskare och beslutsfattare inom både akademi, industri och andra samhällsfunktioner från hela världen fick möjlighet ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Field effect gas sensors have been shown to be very efficient for the detection of hydrogen containing molecules. With the right material combination in terms of catalytic metal contact and gate dielectric ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Three projects are proposed; two fall within molecular/organic electronics, two concern conjugation and aromaticity, and two are based on heavy Group 14 element compounds. Molecular electronic structure ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. ...

Forskningsprojekt från 2017-01-01 till 2018-12-31

Allosteric regulation is fundamental to protein function. HIV-1 protease from drug-treated patients acquires multiple allosteric mutations that resist drugs profoundly with little impact on enzymatic activity ...

Forskningsprojekt från 2017-01-01 till 2018-12-31

We propose a computational investigation of the magnetic and vibrational properties of porphyrin molecules for diagnostic applications. Our e-science investigation builds on the use of large-scale quantum-chemical ...

Forskningsprojekt från 2014-01-01 till 2014-12-31

Sweden is traditionally strong in theoretical and computational chemistry. To maintain this excellence there is a need to meet on regulary basis. Earlier national meetings in this community have been successful ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Here I propose to build a new force field (FF) in a systematic manner where parameters are derived through Bayesian optimization and machine learning. Derivation of the FF will be done in a step-wise fashion ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Fragility fractures are common in Sweden but we don’t know why. With increasing age, the importance of lifestyle seems to become more important than genetic constitution. The significance of diet, physical ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Enzymes are spectacularly proficient catalysts, reducing the timescales of chemical reactions that drive biology from millions of years to fractions of seconds, and there is great interest in understanding ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

THE GOAL OF THIS PROJECT is to answer some important questions related to complex dynamical surfaces, nanoparticles, and their interfaces with water – and to provide a computational strategy to enable ...