Forskning vid Uppsala universitet

Forskningsprojekt från 2019-01-01 till 2024-12-31

A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

Forskningsprojekt från 2016-11-01 till 2016-11-30

The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2013-12-01 till 2017-10-30

Syfte och mål: Syftet för forskningsprojektet var att öka vår förståelse för hur mänskliga kloridjonskanaler- och transportörer fungerar. Ett av målen för projektet var att förklara och direkt visualisera ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

How can we study inherently dynamic and heterogeneous architectures of protein complexes? Most techniques struggle with heterogeneous systems, especially when lowly populated states are crucial for the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

The overall objective of this project is to evaluate the potential of traditional Sri Lankan medicinal plants as a source of novel biolgically active molecules that can be used as leads or tools for medical ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

Sponges (phylum Porifera) are unquestionably the most promising source of new marine compounds and yet, they are quite often neglected in the field of natural products research because of the extreme difficulty ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Background and aim: Our aim is to study the structure and function of the CO2-concentration machinery in phytoplankton and autotrophic bacteria. Competition between O2 and CO2 at the active site of the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

Forskningsprojekt från 2017-01-01 till 2017-03-13

G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Hip fractures annually affect almost 20,000 patients in Sweden. In about 2,000 patients with displaced femoral neck fractures insertion of a total hip arthroplasty (THA) is the best available treatment ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

I Sverige drabbas varje år 70000 individer av en fragilitetsfraktur. Med en livstidstidsrisk om 50 % för kvinnor och 25 % hos män har Sverige en av de högsta förekomsterna i världen av dessa frakturer. ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Background and aimFemoral neck fractures (FNFs) are a great challenge for today´s healthcare and they are associated with high mortality and morbidity in the elderly. The treatment of displaced FNF has ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The packaging of DNA into chromatin regulates a wide range of vital processes. One key class of enzymes that can regulate chromatin structure is the ATP-dependent chromatin remodeling enzymes (remodelers ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Despite significant progress in understanding of bacterial protein synthesis several questions remained unanswered. In this project we aim to address some of the unanswered questions. The large subunit ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

S-adenosyl methionine (SAM) is an essential co-substrate in methylation and a regulatory molecule in bacteria. In bacterial protein synthesis, methylation of rRNA by house-keeping site-specific SAM-dependent ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Non-enveloped icosahedral dsRNA viruses that infect unicellular hosts are transmitted intracellularly. However, phylogenetically closely-related viruses found in multicellular hosts (metazoa) have acquired ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. ...