Forskning vid Uppsala universitet

Forskningsprojekt från 2012-01-01 till 2012-12-31

We have two times previously been organizing a biannual conference in Uppsala with support from Vetenskapsrådet. The first conference, ?Neurodegenerative disorders: immunotherapy and biomarkers? was held ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Stroke is a major cause of mortality and severe disability in the aging population. About 1/3 of strokes are caused by atrial fibrillation (AF) affecting 300,000 patients in Sweden. Oral anticoagulation ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

Background: Annually, 10 000 out-of-hospital cardiac arrests (OHCA) occur in Sweden. Acute Myocardial infarction is the most common cause of OHCA. One third of OHCA patients have ST-elevation on their ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Fibrillar alpha-synuclein in Lewy bodies is the main hallmark in brains of patients with Parkinson´s disease and some other brain disorders. However, recent studies indicate that oligomers or protofibrils ...

Forskningsprojekt från 2013-09-01 till 2014-08-31

Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...

Forskningsprojekt från 2016-01-01 till 2016-12-31

Alzheimer’s disease (AD) is the most prevalent type of dementia. One major challenge in the development of disease modification therapies for AD is the absence of biomarkers reflecting disease progression ...

Forskningsprojekt från 2015-01-01 till 2017-06-30

Astrocytes, the most abundant cell population in the brain, show temporal and regional heterogeneity. Astrocytomas, the most common primary malignant brain tumor in adult patients, are often localized ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

We propose to analyze functionality of neuronal circuits through gene targeting in mice. Our aim is to understand which and how neuronal components affect circuit functionality in health and disease. Firstly ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2015-01-01 till 2020-12-31

Djupare förståelse av miRNA i modellsjukdomar för autoimmunitet och neuromuskulär transmission ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Patients with the autoimmune neuromuscular disorder Myasthenia Gravis (MG) suffer from abnormal muscle fatigue and weakness due to antibody attack of the neuromuscular synapse. MG is considered a model ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Hip fractures annually affect almost 20,000 patients in Sweden. In about 2,000 patients with displaced femoral neck fractures insertion of a total hip arthroplasty (THA) is the best available treatment ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

I Sverige drabbas varje år 70000 individer av en fragilitetsfraktur. Med en livstidstidsrisk om 50 % för kvinnor och 25 % hos män har Sverige en av de högsta förekomsterna i världen av dessa frakturer. ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Background and aimFemoral neck fractures (FNFs) are a great challenge for today´s healthcare and they are associated with high mortality and morbidity in the elderly. The treatment of displaced FNF has ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Peptide toxins have a huge potential as pharmacological agents due to high affinity and selectivity for their target receptors. In the current project we will explore a neglected natural resource to find ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. ...

Forskningsprojekt från 2014-01-01 till 2014-12-31

Den internationella föreningen " The society of research into hydrocephalus and spina bifida (SRHSB)" anordnar i juni 2014 sin 58:e årliga konferens i Uppsala. Målgruppen för konferensen är alla, som har ...

Forskningsprojekt från 2012-03-01 till 2016-10-31

The overarching goal of this proposal is to increase the understanding of human physiology and pathology by combining the information from PET and MRI and deploy this knowledge to guide diagnosis and interventions ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Mutations in the genes for the amyloid precursor protein (APP) and the presenilins cause early-onset, inherited forms of Alzheimer’s disease (AD). We have previously identified and characterized two different ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Fragility fractures are common in Sweden but we don’t know why. With increasing age, the importance of lifestyle seems to become more important than genetic constitution. The significance of diet, physical ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Malignant glioma is the most common brain tumor with invasive growth and no cure. Neural stem cells and glioma-initiating cells have common traits, such as sustained proliferation and efficient migratory ...

Forskningsprojekt från 2012-04-01 till 2015-12-31

Syfte och mål: Parkinsons sjukdom (PD) orsakas av att dopaminproducerande celler i substantia nigra av okänd förstörs och försvinner. En av de rådande teorierna föreslår att oxidativ stress startar förloppet ...

Forskningsprojekt från 2020-12-01 till 2023-12-31

Autoimmune or viral attack of the synapses in the nervous system cause autoimmune myasthenia gravis (MG) at the neuromuscular junction and autoimmune or viral encephalitis in the brain. At present, rodent ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

We focus on human neuropeptide mutations that CAUSE profound neurodegeneration in human brain (Bakalkin et al., 2010). Generalized pathological changes in patients carrying the mutations emphasize a fundamental ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Alzheimer´s disease (AD), dementia with Lewy bodies (DLB) and Parkinson´s disease (PD) are the most common neurodegenerative disorders caused by aggregation of pathological proteins in the brain. In AD ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Much of our knowledge about functions of genes and proteins in human brain has come from analysis of rare mutations representing entry points into novel molecular mechanisms. Neuropeptides, a largest family ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Poor adherence to treatment is the main cause of failure to control hypertension, the leading risk factor for premature deaths worldwide. Improving adherence is imperative. That is the aim of this research ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to perform an investigator-initiated, multicentre, randomized, prospective comparative clinical trial of deep brain stimulation of the subthalamic nuclei (STN-DBS) and levodopa/carbidopa infusion ...