Forskning vid Uppsala universitet

Forskningsprojekt från 2013-01-01 till 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Forskningsprojekt från 2019-07-01 till 2021-06-30

Syfte och mål: Anaplastisk sköldkörtelcancer (ASC) har idag en mycket dålig prognos, och bristen på kurativa behandlingsalternativ för ASC är ett stort problem. Andra typer av sköldkörtelcancer kan framgångsrikt ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Regulatory T cells (Tregs) are immune cells that play a pivotal role in maintaining homeostasis, as well as in autoimmunity, infection and tumor biology. Recent evidence suggests that tissue-specific Tregs ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Immunotherapy has revolutionized cancer treatment and checkpoint inhibitors, which act by removing negative signals in already activated T cells, are predicted tobecome first line treatment for many cancer ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Immunotherapy is currently being established as cancer treatment. Immune checkpoint blockade antibodies that fine-tune T cell activity to attack and kill tumor cells can cure 20-25% of patients with refractory ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A prominent feature in a number of rheumatic diseases is an increased expression in blood and tissue cells of type I interferon regulated genes (an IFN signature), which activates both the innate and adaptive ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Hip fractures annually affect almost 20,000 patients in Sweden. In about 2,000 patients with displaced femoral neck fractures insertion of a total hip arthroplasty (THA) is the best available treatment ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

I Sverige drabbas varje år 70000 individer av en fragilitetsfraktur. Med en livstidstidsrisk om 50 % för kvinnor och 25 % hos män har Sverige en av de högsta förekomsterna i världen av dessa frakturer. ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Background and aimFemoral neck fractures (FNFs) are a great challenge for today´s healthcare and they are associated with high mortality and morbidity in the elderly. The treatment of displaced FNF has ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The over-all purpose of this project is to improve immunotherapy in neurodegenerative diseases by targeting neurotoxic protein aggregates with brain penetrating bispecific antibodies. As antibodies do ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Animal cells maintain tissue function by secreting regulatory factors to signal their activity and nutrient status, pathogen infections or injury. These regulated vesicle fusion events are typically much ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The objectives are to understand how IgM/complement and IgE/the low affinity receptor for IgE (CD23) operate to feedback enhance the immune response and how IgG feedback suppresses antibody responses. ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Antibodies dramatically up- or downregulate the immune response to the antigen they bind and thus, depending on isotype and antigen, act as natural adjuvants or immunosuppressors. IgG-MEDIATED SUPPRESSION ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The aim is to understand how passively administered or endogenously produced Abs, forming immune complexes (ICs) with their Ag, can completely suppress or enhance Ab responses several 100-fold. Special ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

OBJECTIVE: To study immune complex (IC)-mediated mechanisms in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with emphasis on how IC and IC-associated autoantibodies regulate production ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

We recently made three discoveries related to acquired Loss Of chromosome Y (LOY) in blood of adult/aging men. LOY is associated with: a) shorter survival and increased mortality from cancer; b) Alzheimer ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Autoinflammatoriska sjukdomar (AID) karakteriseras av en felreglering av det primära immunförsvaret. Den kliniska bilden utgörs av inflammation utan infektiös eller autoimmun bakomliggande orsak. AID är ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

In this four-year project we will expand, develop and refine the way autoimmune serology is used to characterize and understand the pathogenetic mechanisms leading to individual clinical phenotypes of ...

Forskningsprojekt från 2016-01-01 till 2017-12-31

Autoantibodies, immune complex (IC) deposition, and complement are important factors in many autoimmune diseases. IgM antibodies exert their effect through complement or Fc-receptors. The aim of the current ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...

Forskningsprojekt från 2018-01-01 till 2018-12-31

Immunological research ...