Forskning vid Uppsala universitet

Forskningsprojekt från 2011-01-01 till 2013-12-31

With 70-90% of the new drug-like molecules synthesised at date showing poor water solubility computational tools that allow predictions of the solubility and give suggestions on how to improve this property ...

Forskningsprojekt från 2012-01-01 till 2013-12-31

The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Most molecules have limited ability to cross the blood-brain barrier (BBB), heavily restricting the future expansion of neurotherapeutics development. With the current proposal, we aim to evaluate the ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Detta projekt söker ny kunskap om tidigmodern farmaci genom att rekonstruera försvunna farmaceutiska färdigheter rörande handel med, samt hantering och komposition av mediciner. Varifrån kom substanserna ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Cardiovascular disease (CV) contributes greatly to high mortality and morbidity in diabetes and thus, treatment focuses on controlling risk factors, e.g. hypertension, hyperlipidemia and obesity. However ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The aim of this project is to develop mathematical models, methods and processes that will allow data from composite assessments of patient status to be efficiently utilized with the purpose of improving ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

We hypothesize that alterations in the epigenome in response to adverse events and / or alcohol binging in early life may be a critical factor contributing to risk and resilience to alcohol use disorders ...

Forskningsprojekt från 2015-12-01 till 2018-11-30

The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...

Forskningsprojekt från 2014-08-01 till 2018-07-31

The overall aim of this PhD project is to develop and implement state-of-the-art targeted and global proteomic technologies to understand the role of active processes mediated by transporter proteins and ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Hip fractures annually affect almost 20,000 patients in Sweden. In about 2,000 patients with displaced femoral neck fractures insertion of a total hip arthroplasty (THA) is the best available treatment ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

I Sverige drabbas varje år 70000 individer av en fragilitetsfraktur. Med en livstidstidsrisk om 50 % för kvinnor och 25 % hos män har Sverige en av de högsta förekomsterna i världen av dessa frakturer. ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Cancer is a major public health issue globally and about 25% of all deaths in the EU and USA are due to cancer. Liver cancer, the fifth most common tumor, is often offered a palliative treatment with chemotherapeutic ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the intestinal fluid ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Background and aimFemoral neck fractures (FNFs) are a great challenge for today´s healthcare and they are associated with high mortality and morbidity in the elderly. The treatment of displaced FNF has ...

Forskningsprojekt från 2016-06-01 till 2017-11-30

Syfte och mål: Syftet med projektet var att genom individrörlighet skapa ett utbyte av kunskap och metoder inom läkemedelsutveckling mellan forskare vid Uppsala universitet och AstraZeneca Gothenburg. ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

The main objective of the present research is to study functional protein and peptide neurochemical processes in Parkinson disease (PD) and specifically L-Dopa-induced dyskinesias (LID). No treatment exists ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

The main objective of the present research is to study functional protein, peptide and neurotransmitter neurochemical processes in Parkinson disease (PD) and specifically L-Dopa-induced dyskinesias (LID ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Osteoporotic fractures are common in Sweden. We don?t know why. The significance of lifestyle, comorbidity and genetic constitution on the risk of osteoporotic fractures is going to be examined in a cohort ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Periprosthetic joint infections (PJI) and dislocations are serious early complications after total hip arthroplasty (THA), an operation that is almost as frequent as coronary percutaneous intervention. ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Cancer is a global health issue and about 25% of all deaths in the EU and USA are due to cancer. The primary objective of this cross-disciplinary project is to develop new advanced injectable pharmaceutical ...

Forskningsprojekt från 2016-01-01 till 2020-12-31

Infrastrukturen för masspektrometrisk avbildning vid Uppsala universitet analyserar läkemedel, läkemedelsmetaboliter, peptider, proteiner, lipider och neurotransmittorer i tunna snitt av biologisk vävnad ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Fragility fractures are common in Sweden but we don’t know why. With increasing age, the importance of lifestyle seems to become more important than genetic constitution. The significance of diet, physical ...