Forskning vid Uppsala universitet

Forskningsprojekt från 2012-01-01 till 2012-12-31

This conference explores how the molecules of life link to the phenotype of the organism. In particular, we focus on the frontiers of the three interconnected topics: developmental biology, neurobiology ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Abdominal Aortic Aneurysm (AAA) is an important health problem. Most patients have no symptoms prior to rupture, the only way to decrease mortality is to screen and treat healthy individuals. This is feasible ...

Forskningsprojekt från 2014-07-01 till 2023-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which have increased risk of specific diseases. With mapping tools available, we are in a unique position to map canine disease ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...

Forskningsprojekt från 2014-07-01 till 2015-06-30

Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Knowledge about the cellular mechanisms behind initiation and spreading of Alzheimer’s disease (AD) is still very limited. Decades of research have focused on neuronal abnormalities in AD pathology, but ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Att förklara proteinsyntesen i mykobakterier med hög effekt för riktad läkemedelsutveckling (Beviljad ansökan överförd från Vinnova med dnr 2013-02072) ...

Forskningsprojekt från 2015-01-01 till 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

This project will investigate mechanisms involved in the propagation of pathology in Parkinson´s disease. Recent studies have shown that aggregates of the normally intracellular protein alpha-synuclein ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

Metastasis is thought to involve tumor invasiveness, endothelial transmigration and the ability to seed at distant sites. Endothelial/immune cell interactions have recently been suggested to play a role ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

AIM: To understand molecular mechanisms regulating vascular abnormalization in glioblastoma and to identify vascular targets for cancer therapy. BACKGROUND: Glioblastoma are aggressive brain tumors characterized ...

Forskningsprojekt från 2016-01-01 till 2025-12-31

Over the past 10-15 years, vascular biology has transformed from a mainly medical discipline concerned with thrombosis, hypertension and atherosclerosis into a multifaceted biological science spanning ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The ability of blood vessels to dynamically regulate their permeability to solute, molecules and cells is critical in physiological processes such as wound healing and it is vital for tissue homeostasis ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Campylobacter är den vanligaste bakteriella tarmpatogenen och den vanligast rapporterade zoonosen i Europa. Trots att denna bakterie har en stor påverkan på samhället vet man väldigt lite om hur den orsakar ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Our goal is to, based on cell of origin, stratify glioblastoma (GBM) into novel subclasses of clinical relevance, identify pathways and biomarkers of therapeutic value, and drugs with potency against glioma ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Lymphoma and hemangiosarcoma are both aggressive cancers with poor prognosis. Dogs also develop lymphoma and hemangiosarcoma and make an excellent model system for both diseases. Research shows that dogs ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

DEN PLANERADE KONFERENSENS NAMN OCH PLATS: Griboi och UppsalaTIDPUNKT FÖR KONFERENSEN: 10-12 maj, 2012 KORT MOTIVERING AV KONFERENSEN Sverige har år 2012 för första gången blivit utsett som värdland för ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Currently there are no effective treatments that can cure metastatic breast cancer and therefore patients diagnosed with metastatic disease have an extremely poor prognosis. A critical program underlying ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Background: Adverse drug reactions (ADRs) impose a huge health and economic burden on society. They are a common cause of admission to hospital and as costly as drug treatment itself. We are a national ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The overall aim of the four projects included in this application is to discover novel pathways for the prevention of fractures in older people, a common problem in Sweden. The first project is intended ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

The aim of the project is to identify functional genetic variants in SLE. In the first part of the project we will identify previously unknown genetic variants by comparing DNA samples from SLE patients ...