Forskning vid Uppsala universitet

Forskningsprojekt från 2019-01-01 till 2024-12-31

A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

Forskningsprojekt från 2016-11-01 till 2016-11-30

The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2013-12-01 till 2017-10-30

Syfte och mål: Syftet för forskningsprojektet var att öka vår förståelse för hur mänskliga kloridjonskanaler- och transportörer fungerar. Ett av målen för projektet var att förklara och direkt visualisera ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

How can we study inherently dynamic and heterogeneous architectures of protein complexes? Most techniques struggle with heterogeneous systems, especially when lowly populated states are crucial for the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

The overall objective of this project is to evaluate the potential of traditional Sri Lankan medicinal plants as a source of novel biolgically active molecules that can be used as leads or tools for medical ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

Sponges (phylum Porifera) are unquestionably the most promising source of new marine compounds and yet, they are quite often neglected in the field of natural products research because of the extreme difficulty ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Background and aim: Our aim is to study the structure and function of the CO2-concentration machinery in phytoplankton and autotrophic bacteria. Competition between O2 and CO2 at the active site of the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

Forskningsprojekt från 2017-01-01 till 2017-03-13

G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The packaging of DNA into chromatin regulates a wide range of vital processes. One key class of enzymes that can regulate chromatin structure is the ATP-dependent chromatin remodeling enzymes (remodelers ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Despite significant progress in understanding of bacterial protein synthesis several questions remained unanswered. In this project we aim to address some of the unanswered questions. The large subunit ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

S-adenosyl methionine (SAM) is an essential co-substrate in methylation and a regulatory molecule in bacteria. In bacterial protein synthesis, methylation of rRNA by house-keeping site-specific SAM-dependent ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Non-enveloped icosahedral dsRNA viruses that infect unicellular hosts are transmitted intracellularly. However, phylogenetically closely-related viruses found in multicellular hosts (metazoa) have acquired ...

Forskningsprojekt från 2017-01-01 till 2018-12-31

Allosteric regulation is fundamental to protein function. HIV-1 protease from drug-treated patients acquires multiple allosteric mutations that resist drugs profoundly with little impact on enzymatic activity ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The packaging of DNA as chromatin regulates many important cellular processes that require access to the cell’s genetic material. One major class of enzymes responsible for regulating the structure of ...

Forskningsprojekt från 2012-01-01 till 2017-12-31

The Laboratory of Molecular Biophysics at Uppsala University will provide parts of the bio-imaging instrumentation as a Swedish in-kind contribution to the European XFEL GmbH. This project has been approved ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

The appearance of superbugs producing metallo-beta-lactamases have resulted in a clinical crisis. This project intends to express and purify subclasses of metallo-beta-lactamases including NDM-1. Specific ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Metal ions are essential for life, as structural components of the cellular machinery and catalysts of chemical reactions, yet are toxic at high concentrations. Metal homeostasis is therefore tightly controlled ...

Forskningsprojekt från 2018-05-01 till 2019-06-29

Syfte och mål: Målet med projektet var att utveckla/utvärdera en metod att bekämpa ogräs från drönare. Det visade sig att den ursprungliga idéen att använda laser var problematisk. Däremot visade sig ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Algblomningar har en enorm påverkan på marina ekosystem, mänskliga aktiviteter såsom fiske och strandnöje, samt på människors hälsa. Övervakningen av algblomningar är en av de viktigaste statliga aktiviteterna ...