Forskning vid Uppsala universitet

Forskningsprojekt från 2015-12-01 till 2018-11-30

Genetic factors account for up to 80% of the risk in Alzheimer’s disease (AD). The advent of genomic approaches (such as genome-wide association studies, GWASs) has led to the characterization of 26 genetic ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

The present project will meet the swedish national scientific, industrial and societal demands within high-quality material analysis by sustaining and advancing the role of the Tandem laboratory at Uppsala ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

As an animal moves through the world, its own movement generates widefield optic flow across the visual field used to e.g. maintain a straight trajectory or to avoid obstacles. Many animals can also disambiguate ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The proposed project addresses the formation and function of the spinal locomotor network. This pattern generator operates as an autonomous metronome that creates a rhythmic output to the muscles as well ...

Forskningsprojekt från 2016-01-01 till 2016-12-31

Alzheimer’s disease (AD) is the most prevalent type of dementia. One major challenge in the development of disease modification therapies for AD is the absence of biomarkers reflecting disease progression ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Aim: To develop antibody (mAb) based Positron Emission Tomography (PET) ligands for use in Alzheimer’s (AD) and Parkinson’s disease (PD) with dynamic and specific properties correlating with disease severity.Current ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Knowledge about the cellular mechanisms behind the propagation of Alzheimer’s disease (AD) in the brain is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Knowledge about the cellular mechanisms behind initiation and spreading of Alzheimer’s disease (AD) is still very limited. Decades of research have focused on neuronal abnormalities in AD pathology, but ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

The purpose of this project is to add state-of the-art brain imaging to a double-blind randomized controlled trial of repetitive transcranial magnetic stimulation (rTMS) for the treatment of anhedonia. ...

Forskningsprojekt från 2015-01-01 till 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

This project will investigate mechanisms involved in the propagation of pathology in Parkinson´s disease. Recent studies have shown that aggregates of the normally intracellular protein alpha-synuclein ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Forskningsprojekt från 2014-10-25 till 2015-06-25

Cathepsin S roll i neuropatisk smärta ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Our goal is to, based on cell of origin, stratify glioblastoma (GBM) into novel subclasses of clinical relevance, identify pathways and biomarkers of therapeutic value, and drugs with potency against glioma ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We created a conditional Cre-Lox knock out mice lines of a novel gene ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

We hypothesize that alterations in the epigenome in response to adverse events and / or alcohol binging in early life may be a critical factor contributing to risk and resilience to alcohol use disorders ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Identifiering av celler och molekyler som reglerar smärta och klåda. Smärta får oss att reagera snabbt och undvika det som kan skada oss. En adekvat reaktion kan göra skillnaden mellan en farlig eller ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Midbrain dopamine (DA) neurons of the ventral tegmental area (VTA) and the substantia nigra (SN) form key regulatory circuitries of reward, motivation and movement. Their dysfunction is the core of Parkinson ...

Forskningsprojekt från 2014-08-01 till 2018-07-31

The overall aim of this PhD project is to develop and implement state-of-the-art targeted and global proteomic technologies to understand the role of active processes mediated by transporter proteins and ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

This research project represents novel analytical possibilities in the translational field between analytical chemistry and neurochemistry, including fundamental aspects of sample preparation, multidimensional ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

This research project represents novel analytical possibilities in the translational field between analytical chemistry and neurochemistry, including fundamental aspects of sample preparation, liquid separation ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Alzheimer’s disease (AD) is a multifactorial disorder characterized by amyloid plaques, tau tangles and neurodegeneration. One important process contributing to pathology is the so-called pro-coagulant ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Gene- and immunotherapy against amyloid-beta (Ab) and alpha-synuclein (a-syn) have begun to be explored for Alzheimer’s disease (AD) and Parkinson’s disease (PD). We showed both ex vivo and in vivo that ...

Forskningsprojekt från 2012-01-01 till 2013-10-31

Syfte och mål: Syftet med projektet var dels att upprätta ett samarbete mellan tre forskning/industrismiljöer, dels att förbättra jämställdheten i akademisk miljö. Det vetenskapliga syftet var analys ...

Forskningsprojekt från 2015-01-01 till 2020-12-31

Djupare förståelse av miRNA i modellsjukdomar för autoimmunitet och neuromuskulär transmission ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Patients with the autoimmune neuromuscular disorder Myasthenia Gravis (MG) suffer from abnormal muscle fatigue and weakness due to antibody attack of the neuromuscular synapse. MG is considered a model ...