Forskning vid Uppsala universitet

Forskningsprojekt från 2019-01-01 till 2024-12-31

A new generation of superluminous X-ray free-electron lasers (XFEL) will deliver billions of exposures per day at intensities up to 100-times higher than intensities available from existing XFELs. The ...

Forskningsprojekt från 2016-11-01 till 2016-11-30

The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

Forskningsprojekt från 2017-07-01 till 2020-06-30

In this proposal, we aim to explore the uncharted interactions between the heat released from an exothermic enzymatic reaction, and the enzyme’s structure and function. To achieve this goal, we chose pyruvate ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Amyloid fibers are associated with more than \num{20} human diseasesranging from diabetes to Alzheimer´s. Still, the initiation of fiberformation has eluded scientists because of the many rapidconformational ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Enveloped viruses such as influenza, HIV, and Zika enter cells via a process of membrane fusion between the viral envelope and a cellular membrane, mediated by viral fusion proteins.  The non-protein components ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

We propose to study the structure-function relations of the bacterial ribosome. The ribosome is a large (2.5 MD) macromolecular complex that makes peptide chains with amino acid sequences as prescribed ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The structure and dynamics of biomolecules are intimately coupled to biological function, and numerous diseases are rooted in biomolecular structure. Functionally important conformational states are often ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Protein synthesis has been studied for decades, and we have a detailed picture of the process in vitro. However, when researchers aim to exploit the system, e.g. for recombinant protein production, or ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

In this project we will address the fundamental question of how the genetic information in DNA codes for rates of binding and unbinding, by using p53 - DNA binding as a model system. To answer this question ...

Forskningsprojekt från 2013-01-01 till 2018-12-31

The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

För att effektivt fixera koldioxid kapslar cyanobakterier in Rubisco och karbonanhydras inuti en proteinorganell som kallas karboxysomen. Detta skapar en hög koncentration av koldioxid i närheten av Rubisco ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

Forskningsprojekt från 2015-07-01 till 2015-07-31

Dates: 4-6 November in Uppsala 2015.Web site: www.asmcs.se.Surface and colloid chemistry continues to play an important role in the investigation of biological systems for elucidating basic biological ...

Forskningsprojekt från 2013-09-01 till 2017-08-31

The advent of X-ray free-electron lasers has provided users with beams of unprecedented peak brightness, a billion times brighter than previous sources, and briefness with pulse duration on only a few ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Ett mer storskaligt användande av förnyelsebar energi i vårt samhälle kräver nya lösningar för långtidslagring av energi. I detta sammanhang diskuteras ofta vätgas som en framtida energibärare. Idag begränsas ...

Forskningsprojekt från 2011-05-01 till 2014-04-30

Vi studerar dynamiken i transportnät byggd av slemsvamp Physarum. Huvudmål: 1. Att förstå reologisk mekanik i konstruktion av transportnät i Physarum. 2. Att utveckla en biologiskt realistisk modell ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Intrinsically disordered proteins (IDPs) are common in all life and involved in the intricate network of protein interactions that govern cell function. We want to understand how such interactions emerge ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Long-term storage is a key obstacle for further implementation of renewable energy resources in our society. In this context hydrogen gas is often put forward as a future energy vector. However, today ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

AIMS: To obtain fundamental insights into the molecular basis of protein interactions with metal ions, ligands and other proteins, ultimately related to the chemical principles of regulation of biological ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The project studies the feasibility of incoherent diffractive imaging - a brand new method to determine atomic and electronic structure of condensed matter and molecules. It uses ultrashort and intense ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Intrinsically disordered proteins (IDPs) are common in all domains of life and are often crucial for mediating protein-protein interations in for example cell signaling. In the binding process, IDPs undergo ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

In this project we utilize time-resolved X-ray scattering to investigate photo-induced reaction dynamics in various chemical and biological molecular systems both in crystals and in solution. The program ...