Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2014-07-01 till 2023-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which have increased risk of specific diseases. With mapping tools available, we are in a unique position to map canine disease ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The established chemotherapeutic treatment strategies used in pediatric oncology benefit groups of patients with similar clinical manifestations. Relapsed, chemorefractory, and extramedullary disease remain ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

Technological advances have recently fueled the ascent of personal genomics and the promise of precision medicine. The success of medical genetics in realizing this promise will depend on its capacity ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

MYCN tillhör en familj av MYC-proteiner som är inblandade i mer än hälften av all typ av cancer. Vi studerar MYCN och dess roll i allvarliga hjärntumörer hos barn och vuxna. MYCN är starkt kopplat till ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Lymphoma and hemangiosarcoma are both aggressive cancers with poor prognosis. Dogs also develop lymphoma and hemangiosarcoma and make an excellent model system for both diseases. Research shows that dogs ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...

Forskningsprojekt från 2009-09-01 till 2015-05-31

Miljö för medföljande cancerdiagnostik ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The advent of massively parallel sequencing (MPS) has brought about significant changes genomics research. However, for use of MPS in genetic diagnostics, there are still many unsolved issues including ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

The aim of the project is to identify functional genetic variants in SLE. In the first part of the project we will identify previously unknown genetic variants by comparing DNA samples from SLE patients ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for developing certain diseases. Having developed the tools and resources needed, we are now in ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

We have made three discoveries related to during life acquired Loss Of chromosome Y (LOY) in normal blood cells of aging men. LOY is associated with: a) shorter survival and increased mortality from non-hematological ...

Forskningsprojekt från 2012-01-01 till 2017-12-31

Vårt övergripande mål är att förstå epigenetiska mekanismer för psykiska störningar hos barn och ungdomar. Vi tar upp frågan om förändringar i DNA-metylering orsakade av negativa erfarenheter i den unga ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Obesity is a disease that affects a large proportion of the world´s population. The predicted values in obesity prevalence are concerning since it decreases life quality and poses a high economic burden ...

Forskningsprojekt från 2011-07-01 till 2014-06-30

Syfte och mål: Genom att kombinera våra expertiser inom cancergenomik och patenterad teknik för att genmodifiera humana celler kommer vi att skapa nya prediktiva sjukdomsmodeller av genetiska varianter ...

Forskningsprojekt från 2010-07-01 till 2012-03-01

Syfte och mål: Se projektplan. Förväntade effekter och resultat: Se projektplan. Upplägg och genomförande: Se projektplan. ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Resistance to antibiotics is associated with mutations or genes that increase MIC in vitro, but usually at the cost of reduced fitness. Compensatory evolution to ameliorate fitness costs of resistance ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

One of the central problems of cancer systems biology is to understand the complex molecular changes of cancerous cells and tissues, and use this understanding to support the development of new targeted ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Objective: Identify genetics and mechanisms causing Mendelian disordersSpecific aims: Gene discovery in Mendelian disorders Effects of mutations in Claudin10b and ITPR2 genes in anhidrosis Effects of siRNA ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Genetic control independent of sex hormones is important during the sexual differentiation of the brain. Some of these controllers might be encoded on the chromosome Y. The PI recently reported eleven ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Acute myeloid leukemia (AML) is the most common leukemia among adults, and is associated with a poor outcome. Due to toxicity, the survival rate cannot be improved by intensified treatment with the therapies ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Hypertension is one of the strongest risk factors for morbidity and mortality in cardiovascular diseases, and in most cases unknown - denoted primary hypertension. An estimated 5-15% of the affected individuals ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

We recently made three discoveries related to acquired Loss Of chromosome Y (LOY) in blood of adult/aging men. LOY is associated with: a) shorter survival and increased mortality from cancer; b) Alzheimer ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

In the project we will identify rare functional genetic variants in systemic lupus erythematosus (SLE). We will search for unknown rare genetic variants in Swedish patients with SLE patients by comparing ...

Forskningsprojekt från 2013-01-01 till 2014-12-31

The increase in body weight in humans has reached epidemic proportions and influences the disease panorama in dramatic ways. Humans display great variation in their propensity to gain weight and become ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Autoinflammatoriska sjukdomar (AID) karakteriseras av en felreglering av det primära immunförsvaret. Den kliniska bilden utgörs av inflammation utan infektiös eller autoimmun bakomliggande orsak. AID är ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

Cardiac outflow tract defects are the most important cause of human congenital heart disease (CHD). Mal-alignment of the underlying cono-ventricular region with the overlying great vessels results in several ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

My research program aims to translate robust associations from large-scale genome-wide association studies for coronary artery disease into functional understanding and novel treatments.Candidate genes ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...