Forskning vid Uppsala universitet

Forskningsprojekt från 2013-01-01 till 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Forskningsprojekt från 2019-07-01 till 2021-06-30

Syfte och mål: Anaplastisk sköldkörtelcancer (ASC) har idag en mycket dålig prognos, och bristen på kurativa behandlingsalternativ för ASC är ett stort problem. Andra typer av sköldkörtelcancer kan framgångsrikt ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

The present project will meet the swedish national scientific, industrial and societal demands within high-quality material analysis by sustaining and advancing the role of the Tandem laboratory at Uppsala ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project aims at investigating plant dynamics and forest development in the past (the last 130 000 years) and using this information to assist scientists modelling geographical range shifts in response ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Atmospheric rivers are long narrow bands of large integrated water vapor transport in the troposphere. At land fall they are usually associated with extreme conditions in terms of wind and precipitation ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Oxygen is essential for the health of lake ecosystems, but global climate warming may severely deplete oxygen concentrations by increasing microbial respiration rates and stifling atmospheric exchange. ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Regulatory T cells (Tregs) are immune cells that play a pivotal role in maintaining homeostasis, as well as in autoimmunity, infection and tumor biology. Recent evidence suggests that tissue-specific Tregs ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Immunotherapy has revolutionized cancer treatment and checkpoint inhibitors, which act by removing negative signals in already activated T cells, are predicted tobecome first line treatment for many cancer ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Immunotherapy is currently being established as cancer treatment. Immune checkpoint blockade antibodies that fine-tune T cell activity to attack and kill tumor cells can cure 20-25% of patients with refractory ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The rich archaeological and paleoenvironmental records from the Peloponnese peninsula (Greece) are investigated to provide an integrated understanding of the role of climate and climate change for Bronze ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The overall aim of this plan is to improve the treatment of patients with persistent pain and itch by developing novel pharmaceutical strategies and by increasing our knowledge of how itch and pain is ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

Stora områden (20%) av svensk skogsmark har artificiellt dränerats genom dikning under de senaste århundradena för att öka produktionen av timmer. När dessa diken åldras, måste dikesrensning ofta utföras ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A prominent feature in a number of rheumatic diseases is an increased expression in blood and tissue cells of type I interferon regulated genes (an IFN signature), which activates both the innate and adaptive ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Landscapes are multifaceted archives combining natural forming processes with cultural practises and land use strategies of past generations. The aim of the project is to explore the rich archives of the ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The Paleocene-Eocene Thermal Maximum (PETM), a period of global warming some 55 Ma, was triggered by multiple injections of isotopically light carbon into the atmosphere. Methane venting due to magma intrusion ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

India’s agriculture, economy, water resources and societal well-being heavily rely on the Indian summer monsoon rainfall (ISMR). But ISMR is strongly influenced by the El-Nino Southern Oscillation (ENSO ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The over-all purpose of this project is to improve immunotherapy in neurodegenerative diseases by targeting neurotoxic protein aggregates with brain penetrating bispecific antibodies. As antibodies do ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Current global warming, associated with the rapid release of CO2 by burning of fossil fuels, impacts ecosystems both on land and in the ocean, most notably in polar regions. Marine phytoplankton play a ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Deep sea sediment archives form the backbone of global palaeoclimate understanding. Such palaeoclimate reconstructions rest upon the geological law of superposition; sediment core layers become older with ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Animal cells maintain tissue function by secreting regulatory factors to signal their activity and nutrient status, pathogen infections or injury. These regulated vesicle fusion events are typically much ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Extreme weather events, floods and droughts—problems that are likely to become more frequent and extreme due to climate change— inflict major losses and disproportionally affect lower income countries, ...

Forskningsprojekt från 2018-12-01 till 2022-11-30

Frågeställningarna i projektet är: I vilken utsträckning förändras förekomsten av extrema händelser och omfattningen av påverkan på kustzonen i ett ändrat klimat? Fokus är på stormar, översvämningar och ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The objectives are to understand how IgM/complement and IgE/the low affinity receptor for IgE (CD23) operate to feedback enhance the immune response and how IgG feedback suppresses antibody responses. ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Antibodies dramatically up- or downregulate the immune response to the antigen they bind and thus, depending on isotype and antigen, act as natural adjuvants or immunosuppressors. IgG-MEDIATED SUPPRESSION ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The aim is to understand how passively administered or endogenously produced Abs, forming immune complexes (ICs) with their Ag, can completely suppress or enhance Ab responses several 100-fold. Special ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

OBJECTIVE: To study immune complex (IC)-mediated mechanisms in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), with emphasis on how IC and IC-associated autoantibodies regulate production ...