Forskning vid Uppsala universitet

Forskningsprojekt från 2011-01-01 till 2013-12-31

With 70-90% of the new drug-like molecules synthesised at date showing poor water solubility computational tools that allow predictions of the solubility and give suggestions on how to improve this property ...

Forskningsprojekt från 2012-01-01 till 2013-12-31

The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

The present project will meet the swedish national scientific, industrial and societal demands within high-quality material analysis by sustaining and advancing the role of the Tandem laboratory at Uppsala ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Most molecules have limited ability to cross the blood-brain barrier (BBB), heavily restricting the future expansion of neurotherapeutics development. With the current proposal, we aim to evaluate the ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project aims at investigating plant dynamics and forest development in the past (the last 130 000 years) and using this information to assist scientists modelling geographical range shifts in response ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Atmospheric rivers are long narrow bands of large integrated water vapor transport in the troposphere. At land fall they are usually associated with extreme conditions in terms of wind and precipitation ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Detta projekt söker ny kunskap om tidigmodern farmaci genom att rekonstruera försvunna farmaceutiska färdigheter rörande handel med, samt hantering och komposition av mediciner. Varifrån kom substanserna ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Oxygen is essential for the health of lake ecosystems, but global climate warming may severely deplete oxygen concentrations by increasing microbial respiration rates and stifling atmospheric exchange. ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Cardiovascular disease (CV) contributes greatly to high mortality and morbidity in diabetes and thus, treatment focuses on controlling risk factors, e.g. hypertension, hyperlipidemia and obesity. However ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The rich archaeological and paleoenvironmental records from the Peloponnese peninsula (Greece) are investigated to provide an integrated understanding of the role of climate and climate change for Bronze ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The aim of this project is to develop mathematical models, methods and processes that will allow data from composite assessments of patient status to be efficiently utilized with the purpose of improving ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

We hypothesize that alterations in the epigenome in response to adverse events and / or alcohol binging in early life may be a critical factor contributing to risk and resilience to alcohol use disorders ...

Forskningsprojekt från 2015-12-01 till 2018-11-30

The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...

Forskningsprojekt från 2014-08-01 till 2018-07-31

The overall aim of this PhD project is to develop and implement state-of-the-art targeted and global proteomic technologies to understand the role of active processes mediated by transporter proteins and ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

Stora områden (20%) av svensk skogsmark har artificiellt dränerats genom dikning under de senaste århundradena för att öka produktionen av timmer. När dessa diken åldras, måste dikesrensning ofta utföras ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Landscapes are multifaceted archives combining natural forming processes with cultural practises and land use strategies of past generations. The aim of the project is to explore the rich archives of the ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The Paleocene-Eocene Thermal Maximum (PETM), a period of global warming some 55 Ma, was triggered by multiple injections of isotopically light carbon into the atmosphere. Methane venting due to magma intrusion ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

India’s agriculture, economy, water resources and societal well-being heavily rely on the Indian summer monsoon rainfall (ISMR). But ISMR is strongly influenced by the El-Nino Southern Oscillation (ENSO ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Cancer is a major public health issue globally and about 25% of all deaths in the EU and USA are due to cancer. Liver cancer, the fifth most common tumor, is often offered a palliative treatment with chemotherapeutic ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the intestinal fluid ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Current global warming, associated with the rapid release of CO2 by burning of fossil fuels, impacts ecosystems both on land and in the ocean, most notably in polar regions. Marine phytoplankton play a ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Deep sea sediment archives form the backbone of global palaeoclimate understanding. Such palaeoclimate reconstructions rest upon the geological law of superposition; sediment core layers become older with ...

Forskningsprojekt från 2016-06-01 till 2017-11-30

Syfte och mål: Syftet med projektet var att genom individrörlighet skapa ett utbyte av kunskap och metoder inom läkemedelsutveckling mellan forskare vid Uppsala universitet och AstraZeneca Gothenburg. ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Extreme weather events, floods and droughts—problems that are likely to become more frequent and extreme due to climate change— inflict major losses and disproportionally affect lower income countries, ...