Forskning vid Uppsala universitet

Forskningsprojekt från 2020-01-01 till 2023-12-31

Several nanosafety projects have been funded by the EU (e.g. EU Nanosafety Cluster and SmartNanoTox), however, the standardized process to assess and to predict the toxicity of metal oxide nanoparticles ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

We propose the development of a new class of accelerated recursive expansion methods for electronic structure calculations. Our aim is to substantially reduce the computational effort required by modern ...

Forskningsprojekt från 2015-11-01 till 2015-11-30

Conference name and location: Advancing the Frontiers of (Bio)Chemistry with Valence Bond Approaches. Uppsala University, Sweden.Time for the conference (year-month-day): 2016/06/22-24Justification of ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2017-02-01 till 2018-06-30

Syfte och mål: Projektet hade två mål; (i) att knyta långsiktiga forskningskontakter mellan min grupp vid UU och AstraZeneca och (ii) att utveckla den s.k. foto-SNAr reaktionen. Båda målen har uppfyllts ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

How can we study inherently dynamic and heterogeneous architectures of protein complexes? Most techniques struggle with heterogeneous systems, especially when lowly populated states are crucial for the ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project deals with computational studies in the general areas of biological catalysis and molecular recognition. We emphasize what may be called quantitative computational structural biology, where ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

This project deals with the problem of how enzymes can be shaped by evolution to work under extreme conditions. In particular, we will address cold-adapted enzymes that are able to maintain a high catalytic ...

Forskningsprojekt från 2017-01-01 till 2017-03-13

G protein-coupled receptors (GPCRs) play important roles in numerous physiological processes and are important drug targets for neurological diseases. Breakthroughs in GPCR structural biology and access ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

The project is focused on structure-based strategies for discovery of selective ligands of G protein-coupled receptors (GPCRs) and understanding of GPCR dimerization. The A1 adenosine receptor (A1R) is ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

This project is focused on understanding GPCR dimerization and strategies to discover ligands of receptors using structure-based methods. The A2A adenosine (A2AAR) and D2 dopamine (D2DR) receptors form ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The research program studies contact and symplectic topology and its relations to other geometric fields, in particular to physics inspired low-dimensional topology and knot theory. The main tool is theories ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the intestinal fluid ...

Forskningsprojekt från 2016-06-01 till 2017-11-30

Syfte och mål: Syftet med projektet var att genom individrörlighet skapa ett utbyte av kunskap och metoder inom läkemedelsutveckling mellan forskare vid Uppsala universitet och AstraZeneca Gothenburg. ...

Forskningsprojekt från 2015-07-01 till 2018-06-30

One important role of computer aided drug design is to guide modifications of ligands to improve binding to the protein target. Free energy perturbation (FEP) is one of the most rigorous methods to calculate ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The framework of string compactifications is of undisputed importance to connect string theory to the physics of our world, and has promoted progress in fields ranging from quantum gravity and cosmology ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The Fukaya category is a powerful invariant of exact symplectic manifolds in the form of an A-infinity category, the objects of which consist of (a suitable class of) its Lagrangian submanifolds, while ...

Forskningsprojekt från 2018-10-01 till 2018-11-30

Syfte och mål: Jag deltog i programmet Framtidens Ledare vid STS Forum i Kyoto. Ledande forskare och beslutsfattare inom både akademi, industri och andra samhällsfunktioner från hela världen fick möjlighet ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Field effect gas sensors have been shown to be very efficient for the detection of hydrogen containing molecules. With the right material combination in terms of catalytic metal contact and gate dielectric ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Conserved quantities are important in various areas of physics, as in many cases they provide an essential characterization of a physical system. However, to define the mass, center of mass, angular and ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and the quantum ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

During the past decade there has been an important development of the mathematical tools available for high-energy physics. I have participated in and contributed to this development of Generalized Complex ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Three projects are proposed; two fall within molecular/organic electronics, two concern conjugation and aromaticity, and two are based on heavy Group 14 element compounds. Molecular electronic structure ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This research project aims to study several related topics in higher dimensional Auslander-Reiten theory. Classical Auslander-Reiten theory is an important tool in representation theory of associative ...

Forskningsprojekt från 2017-01-01 till 2018-12-31

Allosteric regulation is fundamental to protein function. HIV-1 protease from drug-treated patients acquires multiple allosteric mutations that resist drugs profoundly with little impact on enzymatic activity ...

Forskningsprojekt från 2017-01-01 till 2018-12-31

We propose a computational investigation of the magnetic and vibrational properties of porphyrin molecules for diagnostic applications. Our e-science investigation builds on the use of large-scale quantum-chemical ...

Forskningsprojekt från 2013-01-01 till 2013-12-31

More than thirty years ago a result derived in the context of superspace supergravity indicated that even the most promising supergravity candidate had problems when viewed as a model for quantum gravity ...

Forskningsprojekt från 2014-01-01 till 2014-12-31

Sweden is traditionally strong in theoretical and computational chemistry. To maintain this excellence there is a need to meet on regulary basis. Earlier national meetings in this community have been successful ...