Forskning vid Uppsala universitet

Forskningsprojekt från 2014-07-01 till 2023-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which have increased risk of specific diseases. With mapping tools available, we are in a unique position to map canine disease ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

MYCN tillhör en familj av MYC-proteiner som är inblandade i mer än hälften av all typ av cancer. Vi studerar MYCN och dess roll i allvarliga hjärntumörer hos barn och vuxna. MYCN är starkt kopplat till ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Lymphoma and hemangiosarcoma are both aggressive cancers with poor prognosis. Dogs also develop lymphoma and hemangiosarcoma and make an excellent model system for both diseases. Research shows that dogs ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...

Forskningsprojekt från 2009-09-01 till 2015-05-31

Miljö för medföljande cancerdiagnostik ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The advent of massively parallel sequencing (MPS) has brought about significant changes genomics research. However, for use of MPS in genetic diagnostics, there are still many unsolved issues including ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for developing certain diseases. Having developed the tools and resources needed, we are now in ...

Forskningsprojekt från 2012-01-01 till 2017-12-31

Vårt övergripande mål är att förstå epigenetiska mekanismer för psykiska störningar hos barn och ungdomar. Vi tar upp frågan om förändringar i DNA-metylering orsakade av negativa erfarenheter i den unga ...

Forskningsprojekt från 2011-07-01 till 2014-06-30

Syfte och mål: Genom att kombinera våra expertiser inom cancergenomik och patenterad teknik för att genmodifiera humana celler kommer vi att skapa nya prediktiva sjukdomsmodeller av genetiska varianter ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Resistance to antibiotics is associated with mutations or genes that increase MIC in vitro, but usually at the cost of reduced fitness. Compensatory evolution to ameliorate fitness costs of resistance ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

One of the central problems of cancer systems biology is to understand the complex molecular changes of cancerous cells and tissues, and use this understanding to support the development of new targeted ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Objective: Identify genetics and mechanisms causing Mendelian disordersSpecific aims: Gene discovery in Mendelian disorders Effects of mutations in Claudin10b and ITPR2 genes in anhidrosis Effects of siRNA ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Genetic control independent of sex hormones is important during the sexual differentiation of the brain. Some of these controllers might be encoded on the chromosome Y. The PI recently reported eleven ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Acute myeloid leukemia (AML) is the most common leukemia among adults, and is associated with a poor outcome. Due to toxicity, the survival rate cannot be improved by intensified treatment with the therapies ...

Forskningsprojekt från 2013-01-01 till 2014-12-31

The increase in body weight in humans has reached epidemic proportions and influences the disease panorama in dramatic ways. Humans display great variation in their propensity to gain weight and become ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Autoinflammatoriska sjukdomar (AID) karakteriseras av en felreglering av det primära immunförsvaret. Den kliniska bilden utgörs av inflammation utan infektiös eller autoimmun bakomliggande orsak. AID är ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

During the past decade there has been an important development of the mathematical tools available for high-energy physics. I have participated in and contributed to this development of Generalized Complex ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Through recent advances in sequencing technology, it has become feasible to determine all coding sequence variants in many individual humans. A major bottleneck in understanding genotype-phenotype relationships ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Friedreich ataxia (FRDA) is a trinucleotide repeat disease, where a specific expansion of GAA repeats in the frataxin (FXN) gene leads to gene silencing and to appearance of the disease. FRDA is a severely ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Recently, a large number of genome-wide association studies (GWAS) have been performed and hundreds of genes have been associated to different diseases and phenotypes in man. However, for most traits only ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Our recent analysis shows that de novo somatic (acquired during lifetime) genetic aberrations in the genome of normal cells accumulate with age, are common in elderly, and thus likely contribute to the ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genetic diseases affecting the skin barrier may seriously impair the patients´ quality of life and may even be lethal in the postnatal period. Common symptoms are wide-spread blistering or general scaling ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Symplectic and contact geometry has its roots in the mathematical description of mechanics. Its modern development was initiated in the early 1980´s with conjectures by Arnold and then shaped by Gromov ...