Forskning vid Uppsala universitet

Forskningsprojekt från 2012-01-01 till 2014-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Forskningsprojekt från 2015-01-01 till 2020-12-31

Acute kidney injury - mechanisms and novel therapeutic targets in large animal models ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The pancreatic islets are a complex micro-organ containing many cell types. The importance of interactions between these cells, particularly islet vasculature, for normal islet endocrine function has lately ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Factors influencing body fat accumulation are poorly understood. Individuals that deposit fat in the liver, muscle and pancreas (ectopic fat) without increasing lean tissue (sarcopenic obesity) are prone ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The research program studies contact and symplectic topology and its relations to other geometric fields, in particular to physics inspired low-dimensional topology and knot theory. The main tool is theories ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The small molecule γ-aminobutyric acid (GABA) is made and released by neurons, the insulin secreting β-cells and some immune cells. GABA is an extracellular signal molecule and a Master Regulator of physiological ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Transforming growth factor beta (TGFbeta) family polypeptides are cytokines regulating cell differentiation including the epithelial-mesenchymal transition (EMT). TGFbeta ligands signal via cell surface ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The framework of string compactifications is of undisputed importance to connect string theory to the physics of our world, and has promoted progress in fields ranging from quantum gravity and cosmology ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The Fukaya category is a powerful invariant of exact symplectic manifolds in the form of an A-infinity category, the objects of which consist of (a suitable class of) its Lagrangian submanifolds, while ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

DA-regulated processes, which range from motor control to emotional control and also involves the ability to experience pleasure, are vital for brain function. Disorders of the DA system, including addiction ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Conserved quantities are important in various areas of physics, as in many cases they provide an essential characterization of a physical system. However, to define the mass, center of mass, angular and ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and the quantum ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

During the past decade there has been an important development of the mathematical tools available for high-energy physics. I have participated in and contributed to this development of Generalized Complex ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

This research project aims to study several related topics in higher dimensional Auslander-Reiten theory. Classical Auslander-Reiten theory is an important tool in representation theory of associative ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Hypoxia is a common finding in chronic kidney injury and shifts in cellular oxygen metabolism generate specific signals that modulate cellular differentiation and function, cell-cell interactions and inflammation ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

BAKGRUND: Ett flertal miljögifter har associerats med negativa hälsoeffekter. Detaljerad kunskap om de bakomliggande mekanismerna för hur dessa miljögifter verkar är dock oftast inte väl kända, speciellt ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Immune cells (leukocytes) have essential roles in many situations in the body and are vital for survival. However, they are also driving detrimental inflammation, contributing to the majority of diseases ...

Forskningsprojekt från 2013-01-01 till 2013-12-31

Frisättningen av insulin och glukagon från de Langerhanska öarnas beta- respektive alfaceller är avgörande för blodsockerregleringen. Störd frisättning av insulin uppfattas idag som orsak till de flesta ...

Forskningsprojekt från 2013-01-01 till 2013-12-31

More than thirty years ago a result derived in the context of superspace supergravity indicated that even the most promising supergravity candidate had problems when viewed as a model for quantum gravity ...