Forskning vid Uppsala universitet

Forskningsprojekt från 2012-01-01 till 2013-12-31

The field of chemical safety predictions aims at establishing the safety of novel chemical structures in silico, using computational models based on existing in vitro and in vivo data. The field is hampered ...

Forskningsprojekt från 2013-01-01 till 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Radionuclide imaging of molecular targets in vivo is a promising way to increase specificity of cancer treatment. Affibody molecules constitute a new type of affinity proteins, which has been developed ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The purpose of this project is to push the limits for oral drug delivery and disposition with the use of breakthrough methodologies and models for accurate and precise prediction of oral drug delivery ...

Forskningsprojekt från 2013-04-01 till 2014-03-31

Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...

Forskningsprojekt från 2015-01-01 till 2017-06-30

Astrocytes, the most abundant cell population in the brain, show temporal and regional heterogeneity. Astrocytomas, the most common primary malignant brain tumor in adult patients, are often localized ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2012-08-01 till 2012-12-31

Huvudsyftet med denna ansökan är att täcka kostnaderna för mig och Lars Lind för vårt deltagande i Dioxin 2012.Resan till Dioxin 2012 har tre syften. Det första är att presentera resultat, det andra att ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

SYFTET med forskningsprogrammet är att undersöka om tidig lågdosexponering (in utero och under digivningsperioden) för Bisfenol A (BPA) stör balansen mellan fettväv och benväv. Sådana förändringar skulle ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

To understand the complex biochemical interactions between drugs and their targets, it is necessary to identify the molecular entities involved and determine their abundance and spatial distribution in ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Anabolic androgenic steroids (AAS) have been shown to increase aggression and also to affect the brain reward system. Behavioral tests demonstrate that AAS increase intake and response to other drugs of ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The research program studies contact and symplectic topology and its relations to other geometric fields, in particular to physics inspired low-dimensional topology and knot theory. The main tool is theories ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Background: Adverse drug reactions (ADRs) impose a huge health and economic burden on society. They are a common cause of admission to hospital and as costly as drug treatment itself. We are a national ...

Forskningsprojekt från 2015-12-01 till 2018-11-30

The CO-ACTION project aims to develop and provide a framework for evaluating and validating the effectiveness of antibiotic (AB)- and non-antibiotic (NA) combinations (COMs) in the preclinical setting ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

Peptides and proteins are objects of great interest as potential new medicines for the treatment of central nervous system (CNS) disorders. However, the transport into the brain is minute due to the blood-brain ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Toxicology testing is one of the main reasons for using experimental animals. We set up a very productive fly (Drosophila) lab, with a range of methodologies, enabling detailed molecular, physiological ...

Forskningsprojekt från 2020-12-01 till 2024-12-31

Background, Population and Aim: To increase the cure rate from colorectal cancer, more effective treatments for metastatic disease are needed. Metastases to the peritoneum is a common and difficult clinical ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...

Forskningsprojekt från 2012-08-01 till 2012-12-31

De senaste åren har ett stort antal vetenskapliga studier presenterat oroväckande resultat om att exponering för bisfenol A (BPA) kan påverka människors hälsa. Bland annat rapporterar epidemiologiska studier ...

Forskningsprojekt från 2020-12-01 till 2023-12-31

Assessing safety of early candidates in drug discovery is currently to a large extent based on animal studies, requiring large amounts of animals every year. The purpose of this project is to validate ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Fler och fler studier rapporterar att exponering för miljökemikalier och nutrienter tidigt i utvecklingen kan inverka på kroniska sjukdomstillstånd i vuxen ålder. Nya studier tyder på att epigenetiska ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Peptide toxins have a huge potential as pharmacological agents due to high affinity and selectivity for their target receptors. In the current project we will explore a neglected natural resource to find ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The framework of string compactifications is of undisputed importance to connect string theory to the physics of our world, and has promoted progress in fields ranging from quantum gravity and cosmology ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Målet med detta projekt är att studera toxicitetsmekanismer för miljöfarliga kemikalier via intelligent datagenerering med hjälp av ett automatiserat laboratorium som styrs av ett system med artificiell ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

The Fukaya category is a powerful invariant of exact symplectic manifolds in the form of an A-infinity category, the objects of which consist of (a suitable class of) its Lagrangian submanifolds, while ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

There is a clinical need to improve both diagnostics and therapy of prostate cancer (PC). I propose to use molecular imaging based on radionuclide targeting against proteins associated with disease progression ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

GABA (gamma-aminobutyric acid) is a small molecule with the highest concentration in our brains where it is the main neurotransmitter that reduces neuronal and neuronal networks excitability. All neurons ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Conserved quantities are important in various areas of physics, as in many cases they provide an essential characterization of a physical system. However, to define the mass, center of mass, angular and ...