Forskning vid Uppsala universitet

Forskningsprojekt från 2013-01-01 till 2014-12-31

This project aims to develop of a novel human ex-vivo whole blood loop system for an improved characterization of therapeutic antibodies in order to avoid irrelevant and unnecessary animal studies. Today ...

Forskningsprojekt från 2014-01-01 till 2015-12-31

Cervical cancer is the second most frequent cancer in women and caused by persistent infection by human papillomavirus (HPV). The organised screening in Sweden has reduced the incidence of cervical cancer ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2013-01-01 till 2014-12-31

Prostate cancer is the leading cause of death in men. The diagnosis and prognosis is based on Gleason grading which is the most widely used system for determining the severity of prostate cancer from tissue ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Background: A recent retrospective analysis of 2,173 patients indicated that 5-year survival may differ up to 5% depending on the choice of anaesthetic. Sevoflurane, an inhalational anaesthetic, is pro-inflammatory ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Our goal is to, based on cell of origin, stratify glioblastoma (GBM) into novel subclasses of clinical relevance, identify pathways and biomarkers of therapeutic value, and drugs with potency against glioma ...

Forskningsprojekt från 2009-09-01 till 2015-05-31

Miljö för medföljande cancerdiagnostik ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is clinically and biologically heterogeneous and remains incurable. The etiology is unknown. Our main goals ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is a translational project with a twin focus: A/ adrenocortical carcinoma (ACC) and B/ pancreatic endocrine tumors. A/ We have run a phase III randomized, prospective, controlled, open -label ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Transforming growth factor beta (TGFbeta) family polypeptides are cytokines regulating cell differentiation including the epithelial-mesenchymal transition (EMT). TGFbeta ligands signal via cell surface ...

Forskningsprojekt från 2011-07-01 till 2014-06-30

Syfte och mål: Genom att kombinera våra expertiser inom cancergenomik och patenterad teknik för att genmodifiera humana celler kommer vi att skapa nya prediktiva sjukdomsmodeller av genetiska varianter ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

One of the central problems of cancer systems biology is to understand the complex molecular changes of cancerous cells and tissues, and use this understanding to support the development of new targeted ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

Cancer Related Fatigue (CRF) is reported in up to 90% of cancer patients. It can arise at any point in the course of the disease and is often very self-limited and persists for years. CRF has serious impact ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

In this project, we will combine radio-immunotherapy (RIT) with p53 therapy. RIT is a way to deliver a radiation dose to the malignant cells much more specifically than with current external radiation ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

During the past decade there has been an important development of the mathematical tools available for high-energy physics. I have participated in and contributed to this development of Generalized Complex ...

Forskningsprojekt från 2013-08-01 till 2016-07-31

Livmoderhalscancer är den tredje vanligaste cancerformen hos kvinnor och orsakas av humant papillomvirus (HPV). Endast en liten del av HPV-infektionerna leder till cancer, vilket tyder på att både virus ...

Forskningsprojekt från 2012-03-01 till 2016-10-31

The overarching goal of this proposal is to increase the understanding of human physiology and pathology by combining the information from PET and MRI and deploy this knowledge to guide diagnosis and interventions ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Malignant glioma is the most common brain tumor with invasive growth and no cure. Neural stem cells and glioma-initiating cells have common traits, such as sustained proliferation and efficient migratory ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

BACKGROUND: Epigenetics are changes in the genome function that does not occur in the DNA sequence and that can be inherited to daughter cells and sometimes to the offspring. Epigenetic changes in the ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The interest in mapping mechanisms regulating apoptosis has grown in the light of an established role for survival circuits in tumourigenesis and therapeutic targeting. Previously accomplished research ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

We previously described an animal model in where the human oncogene MYCN induces medulloblastoma (MB), a malignant brain tumor in the small brain, cerebellum. We found that these tumors originate from ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Oncolytic virus therapy, i.e. the use of genetically modified viruses that selectively replicate in and destroy tumors, is an emerging therapeutic approach for cancer. This application focus on the development ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Prostate cancer (Pca) is the most common cancer in Sweden and there is a need for research on etiology, treatment and outcomes. In Sweden existing cancer quality registers can be combined with data from ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Symplectic and contact geometry has its roots in the mathematical description of mechanics. Its modern development was initiated in the early 1980´s with conjectures by Arnold and then shaped by Gromov ...

Forskningsprojekt från 2010-01-01 till 2015-12-31

Vi avser utnyttja en unik samling tekniker, reagens, prover och klinisk expertis för att utveckla en ny generation proteinanalytiska redskap och markörer för individualiserat terapival vid grovtarmscancer ...