Forskning vid Uppsala universitet

Forskningsprojekt från 2012-01-01 till 2015-12-31

The proposed research is a multifaceted investigation centering on problems in homogeneous dynamics and fundamental questions about lattices. We will focus in particular on problems which hold the promise ...

Forskningsprojekt från 2013-01-01 till 2018-12-31

The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

A grand challenge for the 21st century is to develop a molecular-level understanding of a living cell. A key step in this direction is to obtain structures for individual cell organelles. The structure ...

Forskningsprojekt från 2013-09-01 till 2017-08-31

The advent of X-ray free-electron lasers has provided users with beams of unprecedented peak brightness, a billion times brighter than previous sources, and briefness with pulse duration on only a few ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Life processes depend critically on interactions between macromolecules. Many of these interactions involve coupled folding and binding, which lies at the heart of many biologically, medically, and technologically ...

Forskningsprojekt från 2011-05-01 till 2014-04-30

Vi studerar dynamiken i transportnät byggd av slemsvamp Physarum. Huvudmål: 1. Att förstå reologisk mekanik i konstruktion av transportnät i Physarum. 2. Att utveckla en biologiskt realistisk modell ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

AIMS: To obtain fundamental insights into the molecular basis of protein interactions with metal ions, ligands and other proteins, ultimately related to the chemical principles of regulation of biological ...

Forskningsprojekt från 2011-01-01 till 2015-12-31

This proposal brings together those who developed the scientific case in biology for building X-ray lasers (Uppsala) with the team that leads the world in synchrotron-based X-ray crystallography and the ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Intrinsically disordered proteins (IDPs) are very common, in particular among signalling proteins. There are several hypotheses explaining why they are so common, but a paucity of experimental data to ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

In this project we utilize time-resolved X-ray scattering to investigate photo-induced reaction dynamics in various chemical and biological molecular systems both in crystals and in solution. The program ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Proteins are the workhorses of all living cells, they participate in all metabolic activities. The biological function of a protein is intimately linked to its shape, and the protein folding problem addresses ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Biological imaging using Free-Electron Laser (FEL) pulses has in the last two years manifested its great potential. In summary we have demonstrated: i) That it is possible to get high quality atomic resolution ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

The main objective is to develop new technology for studying gene regulation at high spatial and temporal resolution in living cells. The methods will be used to answer fundamental questions about how ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project studies the mathematical models arising from a variety of imaging techniques. These problems are formulated mathematically as "inverse problems" where one deduces information about the differential ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

This project is in the area of Theoretical and Mathematical Physics. The main emphasis is on the development of new geometrical ideas and concepts originating from the modern string theory and ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

During the past decade there has been an important development of the mathematical tools available for high-energy physics. I have participated in and contributed to this development of Generalized Complex ...

Forskningsprojekt från 2012-01-01 till 2017-12-31

The Laboratory of Molecular Biophysics at Uppsala University will provide parts of the bio-imaging instrumentation as a Swedish in-kind contribution to the European XFEL GmbH. This project has been approved ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This proposal aims to put in place the necessary software infrastructure to unleash the full potential of X-ray lasers for imaging. X-ray lasers are billions of times more brilliant than previous light ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

It is proposed to use molecular simulation and classical force fields to study open problems in virology, antibiotic peptides and molecular liquids. The structure of the viral genome remains one of the ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Photosynthesis converts solar energy to chemical energy and key reactions serve as guidelines for the design of artificial photosynthesis to produce solar fuel. The key reaction is catalyzed by Photosystem ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Malfunction in cellular signaling is the cause of a wide variety of human diseases. Efficient and accurate flow of cellular information relies on scaffolding proteins that coordinate the physical assembly ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

This project aims to advance the state-of-the art in applying light from X-ray Free Laser (FEL) facilities to solve the structure of viruses and their genomes. It will build upon on recent breakthroughs ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The ribosomal stalk is a flexible extension on the 50S subunit, composed of dimeric L12 proteins attached to protein L10 that constitutes the stalk-base together with protein L11. The translational GTPases ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Symplectic and contact geometry has its roots in the mathematical description of mechanics. Its modern development was initiated in the early 1980´s with conjectures by Arnold and then shaped by Gromov ...

Forskningsprojekt från 2013-07-01 till 2015-06-30

Extracting detailed three-dimensional structural information from a single biological object with common X-ray sources is problematic if the object is non-reproducible. Here, we propose a new approach ...