Forskning vid Uppsala universitet

Forskningsprojekt från 2017-07-01 till 2020-06-30

In this proposal, we aim to explore the uncharted interactions between the heat released from an exothermic enzymatic reaction, and the enzyme’s structure and function. To achieve this goal, we chose pyruvate ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

In this project we will address the fundamental question of how the genetic information in DNA codes for rates of binding and unbinding, by using p53 - DNA binding as a model system. To answer this question ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Last year marked the emergence of DNA sequencing-based microscopy: methods to produce optics-free microscopic images by encoding spatial information in DNA sequence format prior to recovering that information ...

Forskningsprojekt från 2015-07-01 till 2018-06-30

The association of seven transmembrane helices with the lipid bilayer of a biological cell is both what structurally defines G-protein coupled receptors (GPCR), and what makes them very difficult to study ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Metamonads are a group of anaerobic eukaryotic microbes home to multiple parasites that infect hundreds of millions of people yearly and cause substantial economic damage. They feature a wide variety of ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Non-enveloped icosahedral dsRNA viruses that infect unicellular hosts are transmitted intracellularly. However, phylogenetically closely-related viruses found in multicellular hosts (metazoa) have acquired ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Metal ions are essential for life, as structural components of the cellular machinery and catalysts of chemical reactions, yet are toxic at high concentrations. Metal homeostasis is therefore tightly controlled ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Immunotherapy is the most promising strategy for treatment of dementia despite the fact that antibodies pass poorly through the blood brain barrier (BBB). We have previously developed a BBB transporter ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

The important role of globins to human health has attracted a large body of research. However, the existing research does not emphasize the fundamental redox chemistry and identify the early-time intermediates ...

Forskningsprojekt från 2011-07-01 till 2012-12-31

The objective is to build up an active collaboration between two research groups with complementary competence; Suparna Sanyal, Uppsala (SS) and Marc Blondel, Brest (MB), connecting two cutting-edge research ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The world is facing an increasing difficulty to treat bacterial infections due to the emergence of antibiotic resistance. Meeting this challenge requires innovative approaches to reveal the complex mechanisms ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Electron transfer reactions, executed by redox proteins, are an essential part of many important biological processes such as photosynthesis, respiration, and DNA synthesis. Moreover, several human diseases ...

Forskningsprojekt från 2017-07-01 till 2020-06-30

I plan to use the new technique “time-resolved cryo-electron microscopy (TR cryo-EM)” for structural and kinetics analyses of accuracy of genetic code translation into proteins by transfer RNAs (tRNAs) ...