Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Forskningsprojekt från 2015-12-01 till 2018-11-30

Genetic factors account for up to 80% of the risk in Alzheimer’s disease (AD). The advent of genomic approaches (such as genome-wide association studies, GWASs) has led to the characterization of 26 genetic ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

The present project will meet the swedish national scientific, industrial and societal demands within high-quality material analysis by sustaining and advancing the role of the Tandem laboratory at Uppsala ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

As an animal moves through the world, its own movement generates widefield optic flow across the visual field used to e.g. maintain a straight trajectory or to avoid obstacles. Many animals can also disambiguate ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The proposed project addresses the formation and function of the spinal locomotor network. This pattern generator operates as an autonomous metronome that creates a rhythmic output to the muscles as well ...

Forskningsprojekt från 2016-01-01 till 2016-12-31

Alzheimer’s disease (AD) is the most prevalent type of dementia. One major challenge in the development of disease modification therapies for AD is the absence of biomarkers reflecting disease progression ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Aim: To develop antibody (mAb) based Positron Emission Tomography (PET) ligands for use in Alzheimer’s (AD) and Parkinson’s disease (PD) with dynamic and specific properties correlating with disease severity.Current ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

En stor utmaning i framtiden är att kunna producera tillräckligt med livsmedel åt en växande världsbefolkning på ett effektivt och miljövänligt sätt. Nya strategier behövs för att avla fram grödor och ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Knowledge about the cellular mechanisms behind the propagation of Alzheimer’s disease (AD) in the brain is limited. Decades of research have focused on neuronal abnormalities in AD, but recently more attention ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Knowledge about the cellular mechanisms behind initiation and spreading of Alzheimer’s disease (AD) is still very limited. Decades of research have focused on neuronal abnormalities in AD pathology, but ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

The purpose of this project is to add state-of the-art brain imaging to a double-blind randomized controlled trial of repetitive transcranial magnetic stimulation (rTMS) for the treatment of anhedonia. ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

Forskningsprojekt från 2015-01-01 till 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

This project will investigate mechanisms involved in the propagation of pathology in Parkinson´s disease. Recent studies have shown that aggregates of the normally intracellular protein alpha-synuclein ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Recent data from our lab suggest that L-DOPA-induced dyskinesia (LID) in Parkinson´s disease (PD) is associated with abnormal opioid peptide metabolism in the striatum, but not in the projection target ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2014-10-25 till 2015-06-25

Cathepsin S roll i neuropatisk smärta ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Our goal is to, based on cell of origin, stratify glioblastoma (GBM) into novel subclasses of clinical relevance, identify pathways and biomarkers of therapeutic value, and drugs with potency against glioma ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Microorganisms drive biogeochemical processes and cycling of most biologically active elements in the biosphere. These ecosystem processes are critical for our long-term existence on earth, yet our knowledge ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We created a conditional Cre-Lox knock out mice lines of a novel gene ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...