Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2014-07-01 till 2023-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which have increased risk of specific diseases. With mapping tools available, we are in a unique position to map canine disease ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The established chemotherapeutic treatment strategies used in pediatric oncology benefit groups of patients with similar clinical manifestations. Relapsed, chemorefractory, and extramedullary disease remain ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

En stor utmaning i framtiden är att kunna producera tillräckligt med livsmedel åt en växande världsbefolkning på ett effektivt och miljövänligt sätt. Nya strategier behövs för att avla fram grödor och ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

Technological advances have recently fueled the ascent of personal genomics and the promise of precision medicine. The success of medical genetics in realizing this promise will depend on its capacity ...

Forskningsprojekt från 2014-01-01 till 2018-12-31

MYCN tillhör en familj av MYC-proteiner som är inblandade i mer än hälften av all typ av cancer. Vi studerar MYCN och dess roll i allvarliga hjärntumörer hos barn och vuxna. MYCN är starkt kopplat till ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Microorganisms drive biogeochemical processes and cycling of most biologically active elements in the biosphere. These ecosystem processes are critical for our long-term existence on earth, yet our knowledge ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Lymphoma and hemangiosarcoma are both aggressive cancers with poor prognosis. Dogs also develop lymphoma and hemangiosarcoma and make an excellent model system for both diseases. Research shows that dogs ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent evidence suggests that the leukemia stem cell (LSC) population in acute myeloid leukemia (AML) is diverse, consisting of both dominant and dormant clones. In many cases, dormant clones persist after ...

Forskningsprojekt från 2009-09-01 till 2015-05-31

Miljö för medföljande cancerdiagnostik ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Projektet syftar till att skapa ny kunskap om samutveckling mellan retrovirus och värdar genom att studera naturlig variation bland endogena retrovirus (ERV) inom och mellan värdpopulationer. Virus måste ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Last year marked the emergence of DNA sequencing-based microscopy: methods to produce optics-free microscopic images by encoding spatial information in DNA sequence format prior to recovering that information ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Over the past few years, new sequencing technologies have led to the discovery of novel types of RNA and novel catalytic functions for RNA in the cell. RNA-sequencing has further increased the ability ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The advent of massively parallel sequencing (MPS) has brought about significant changes genomics research. However, for use of MPS in genetic diagnostics, there are still many unsolved issues including ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

The aim of the project is to identify functional genetic variants in SLE. In the first part of the project we will identify previously unknown genetic variants by comparing DNA samples from SLE patients ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for developing certain diseases. Having developed the tools and resources needed, we are now in ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Ända sedan människan påbörjade domesticeringen av våra husdjur och kulturväxter har man utnyttjat genetiken för att skapa raser och sorter med önskvärda egenskaper. Trots att domesticeringen, och senare ...