Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Forskningsprojekt från 2015-01-01 till 2020-12-31

Acute kidney injury - mechanisms and novel therapeutic targets in large animal models ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Acute kidney injury (AKI) is a major clinical problem with no effective treatment and poorly defined pathogenesis. Our preliminary data using unique large animal models indicate that septic AKI is independent ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

En stor utmaning i framtiden är att kunna producera tillräckligt med livsmedel åt en växande världsbefolkning på ett effektivt och miljövänligt sätt. Nya strategier behövs för att avla fram grödor och ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The pancreatic islets are a complex micro-organ containing many cell types. The importance of interactions between these cells, particularly islet vasculature, for normal islet endocrine function has lately ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Factors influencing body fat accumulation are poorly understood. Individuals that deposit fat in the liver, muscle and pancreas (ectopic fat) without increasing lean tissue (sarcopenic obesity) are prone ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

Microorganisms drive biogeochemical processes and cycling of most biologically active elements in the biosphere. These ecosystem processes are critical for our long-term existence on earth, yet our knowledge ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

We aim to study the molecular mechanisms of food intake and reward functions, considering genetic background and cognitive functions. We plan to combine fly, mouse and human genetic models to unravel modes ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Projektet syftar till att skapa ny kunskap om samutveckling mellan retrovirus och värdar genom att studera naturlig variation bland endogena retrovirus (ERV) inom och mellan värdpopulationer. Virus måste ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

The purpose of this project is to generate new knowledge about co-evolution among retroviruses and their hosts by studying natural variation in the endogenous retrovirus (ERV) record within and across ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Phosphorylation and ubiquitination are among the most common post-translational modifications (PTMs) and regulate together most cellular processes. The PTMs are catalyzed by more than 500 kinases and 600 ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Last year marked the emergence of DNA sequencing-based microscopy: methods to produce optics-free microscopic images by encoding spatial information in DNA sequence format prior to recovering that information ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Genome-wide association studies (GWAS) have provided insight into the genetic architecture of many chronic diseases, but translation of this knowledge into clinical practice has been limited. One reason ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

The small molecule γ-aminobutyric acid (GABA) is made and released by neurons, the insulin secreting β-cells and some immune cells. GABA is an extracellular signal molecule and a Master Regulator of physiological ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Over the past few years, new sequencing technologies have led to the discovery of novel types of RNA and novel catalytic functions for RNA in the cell. RNA-sequencing has further increased the ability ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The advent of massively parallel sequencing (MPS) has brought about significant changes genomics research. However, for use of MPS in genetic diagnostics, there are still many unsolved issues including ...

Forskningsprojekt från 2015-01-01 till 2017-12-31

Why some persons develop type 1 diabetes mellitus is still largely unknown. The incidence of this disease is increasing worldwide, but the reasons for the onset of the autoimmune process killing the insulin-producing ...