Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Forskningsprojekt från 2012-01-01 till 2012-12-31

This conference explores how the molecules of life link to the phenotype of the organism. In particular, we focus on the frontiers of the three interconnected topics: developmental biology, neurobiology ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The vast majority of modern pharmacologically active compounds demands advanced drug delivery systems (ADDSs) to be developed as orally administered medicines. The goal for this project is to design lab ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Abdominal Aortic Aneurysm (AAA) is an important health problem. Most patients have no symptoms prior to rupture, the only way to decrease mortality is to screen and treat healthy individuals. This is feasible ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2014-07-01 till 2023-12-31

The domestic dog encompasses hundreds of genetically isolated breeds, many of which have increased risk of specific diseases. With mapping tools available, we are in a unique position to map canine disease ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Angiopoietin-1 (Angpt1) and Angiopoietin-2 (Angpt2) bind to the tyrosine kinase receptor, Tek, found on endothelial cells. Angpt1 is a Tek agonist and promotes endothelial cell stabilization, whereas Angpt2 ...

Forskningsprojekt från 2014-07-01 till 2015-06-30

Anmälan om utnyttjande av återvändarbidrag för beviljade postdoktorsstipendier inom medicin eller natur- och teknikvetenskap ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

En stor utmaning i framtiden är att kunna producera tillräckligt med livsmedel åt en växande världsbefolkning på ett effektivt och miljövänligt sätt. Nya strategier behövs för att avla fram grödor och ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Knowledge about the cellular mechanisms behind initiation and spreading of Alzheimer’s disease (AD) is still very limited. Decades of research have focused on neuronal abnormalities in AD pathology, but ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Att förklara proteinsyntesen i mykobakterier med hög effekt för riktad läkemedelsutveckling (Beviljad ansökan överförd från Vinnova med dnr 2013-02072) ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

Forskningsprojekt från 2015-01-01 till 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

This project will investigate mechanisms involved in the propagation of pathology in Parkinson´s disease. Recent studies have shown that aggregates of the normally intracellular protein alpha-synuclein ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

Metastasis is thought to involve tumor invasiveness, endothelial transmigration and the ability to seed at distant sites. Endothelial/immune cell interactions have recently been suggested to play a role ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Mast cells are currently emerging as major players in a variety of pathologies, but the mechanisms by which they exert such diverse functions remain to be elucidated. A hallmark feature of mast cells is ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

Glioblastomas are aggressive gliomas with a grim prognosis, characterized extreme invasiveness and abnormal vessels. The abnormal vessels can promote tumor progession by providing a route of invasion for ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

AIM: To understand molecular mechanisms regulating vascular abnormalization in glioblastoma and to identify vascular targets for cancer therapy. BACKGROUND: Glioblastoma are aggressive brain tumors characterized ...

Forskningsprojekt från 2016-01-01 till 2025-12-31

Over the past 10-15 years, vascular biology has transformed from a mainly medical discipline concerned with thrombosis, hypertension and atherosclerosis into a multifaceted biological science spanning ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

The ability of blood vessels to dynamically regulate their permeability to solute, molecules and cells is critical in physiological processes such as wound healing and it is vital for tissue homeostasis ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

Campylobacter är den vanligaste bakteriella tarmpatogenen och den vanligast rapporterade zoonosen i Europa. Trots att denna bakterie har en stor påverkan på samhället vet man väldigt lite om hur den orsakar ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...