Forskning vid Uppsala universitet

Forskningsprojekt från 2016-07-01 till 2019-06-30

The overall aim is to understand platelet biogenesis, development and reactivity. The first two years of training will be in the host institute abroad, i.e., Framingham heart study (FHS), National Institutes ...

Forskningsprojekt från 2016-11-01 till 2016-11-30

The 21th Swedish Conference on Macromolecular Structure & Function.Tällberg, June 16-19, 2016Structural biology, Biochemistry, Biophysics & Molecular Biology are strong areas in Swedish research. The Swedish ...

Forskningsprojekt från 2011-01-01 till 2011-12-31

Denna konferens är den 7:e i en serie av möten inom marin naturproduktforskning som anordnas vartannat år av Europeiska forskare. Professor Lars Bohlin med medarbetare har fått hedersuppdraget att för ...

Forskningsprojekt från 2012-01-01 till 2012-12-31

This conference explores how the molecules of life link to the phenotype of the organism. In particular, we focus on the frontiers of the three interconnected topics: developmental biology, neurobiology ...

Forskningsprojekt från 2017-07-01 till 2020-06-30

In this proposal, we aim to explore the uncharted interactions between the heat released from an exothermic enzymatic reaction, and the enzyme’s structure and function. To achieve this goal, we chose pyruvate ...

Forskningsprojekt från 2021-01-01 till 2024-12-31

CRISPR-Cas-based adaptive immune systems are ubiquitous in bacteria and archaea. Paradoxically, CRISPR-associated endonucleases are remarkably slow at locating target DNA, with search times on the order ...

Forskningsprojekt från 2018-12-01 till 2021-12-31

At the core of this project is the question how a cell coordinates growth with DNA replication. We have recently shown that the bacterium E. coli does this by triggering replication initiation at a fixed ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

The long-term goal of my research program is to unravel the functional link between soil fungal communities and nutrient and carbon cycling in terrestrial ecosystems. This is achieved by first establishing ...

Forskningsprojekt från 2015-11-01 till 2015-11-30

Conference name and location: Advancing the Frontiers of (Bio)Chemistry with Valence Bond Approaches. Uppsala University, Sweden.Time for the conference (year-month-day): 2016/06/22-24Justification of ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Fibrillar alpha-synuclein in Lewy bodies is the main hallmark in brains of patients with Parkinson´s disease and some other brain disorders. However, recent studies indicate that oligomers or protofibrils ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Computer simulation is a tool for better understanding of the reactions between molecules and their diffusion in living cells. There are now experimental data for single molecules to compare with and for ...

Forskningsprojekt från 2017-01-01 till 2022-12-31

Uppsala university has excelled in ribosome research over decades and already has a strong environment in the area of bacterial protein synthesis. We aim here at creating a novel type of ribosome research ...

Forskningsprojekt från 2011-08-22 till 2011-12-31

Det finns ett brådskande behov av att utveckla hållbara lösningar för att omvandla solenergi till energibärare som används i samhället. Förutom nuvarande och framtida solceller som producerar el finns ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Generation of architectural polarity impacts all cell types, ranging from epithelial cells to neurons and astrocytes, relates to tissue organization and links to disease development when misregulated. ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

En stor utmaning i framtiden är att kunna producera tillräckligt med livsmedel åt en växande världsbefolkning på ett effektivt och miljövänligt sätt. Nya strategier behövs för att avla fram grödor och ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Each branch of the tree of life includes a myriad of parasitic species but current research does not adequately represent their remarkable diversity. Today, entire parasitic groups have eluded characterization ...

Forskningsprojekt från 2020-08-01 till 2020-12-31

Low molecular-weight heparin (LMWH) has rapidly become a primary drug in treatment of Covid-19 patients. A major rationale is the pulmonary coagulopathy typical of the seriously ill patient. Increasing ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

We propose to study the structure-function relations of the bacterial ribosome. The ribosome is a large (2.5 MD) macromolecular complex that makes peptide chains with amino acid sequences as prescribed ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The ribosome is a large macromolecular complex of two subunits. It links amino acids into proteins according to the messenger RNA (mRNA) instructions. The twenty amino acids (aa) are covalently coupled ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Genotype-to-phenotype mapping is a core feature of genetics. These maps describe how combinations of DNA variants (genotypes) contribute to the appearance (the phenotype) of an individual organism. Staggering ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Protein synthesis has been studied for decades, and we have a detailed picture of the process in vitro. However, when researchers aim to exploit the system, e.g. for recombinant protein production, or ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

In this project we will address the fundamental question of how the genetic information in DNA codes for rates of binding and unbinding, by using p53 - DNA binding as a model system. To answer this question ...

Forskningsprojekt från 2015-01-01 till 2015-12-31

I have previously identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters for amino acids. A number of these were evolutionary ...

Forskningsprojekt från 2016-01-01 till 2019-12-31

Over the next decades, dramatic increases of obesity and type 2 diabetes are expected in the U.S. and throughout the world. As insulin resistance is a usual intermediate step between obesity, type 2 diabetes ...

Forskningsprojekt från 2013-01-01 till 2018-12-31

The overall ambition is to make intracellular measurements that bridge the gap between quantitative physical models and biological observations in order to identify and resolve inconsistencies in our current ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

To accelerate CO2 fixation, cyanobacteria encapsulate Rubisco and carbonic anhydrase within a protein organelle called the carboxysome. This provides Rubisco with a high concentration of CO2 and protects ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

För att effektivt fixera koldioxid kapslar cyanobakterier in Rubisco och karbonanhydras inuti en proteinorganell som kallas karboxysomen. Detta skapar en hög koncentration av koldioxid i närheten av Rubisco ...

Forskningsprojekt från 2013-07-01 till 2016-06-30

The HIV/AIDS pandemic is still one of the most serious threats to human health, causing 1.7 million deaths in 2011 alone. Efforts to produce a vaccine to prevent HIV infection, which is needed to limit ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

The aim is to study the structure and function of the CO2-concentration machinery in phytoplankton. Competition between O2 and CO2 at the active site of the CO2-fixing enzyme, Rubisco, reduces the efficiency ...